KEGG   DRUG: MephenytoinHelp
Entry
D00375                      Drug                                   

Name
Mephenytoin (USP/INN);
Mesantoin (TN)
Formula
C12H14N2O2
Exact mass
218.1055
Mol weight
218.2518
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02031  Hydantoin antiepileptics
Cyp substrate
 DG01639  CYP2C19 substrate
Remark
ATC code: N03AB04
Efficacy
Anticonvulsant
Comment
Hydantoin derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB04 Mephenytoin
      D00375  Mephenytoin (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00375  Mephenytoin (USP/INN)
    SCN2A
     D00375  Mephenytoin (USP/INN)
    SCN3A
     D00375  Mephenytoin (USP/INN)
    SCN4A
     D00375  Mephenytoin (USP/INN)
    SCN5A
     D00375  Mephenytoin (USP/INN)
    SCN8A
     D00375  Mephenytoin (USP/INN)
    SCN9A
     D00375  Mephenytoin (USP/INN)
    SCN10A
     D00375  Mephenytoin (USP/INN)
    SCN11A
     D00375  Mephenytoin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 50-12-4
PubChem: 7847441
ChEBI: 6757
ChEMBL: CHEMBL861
DrugBank: DB00532
LigandBox: D00375
NIKKAJI: J4.097E
KCF data Show

ATOM        16
            1   C1z C    20.8941  -17.2706
            2   C5x C    19.4767  -17.2762
            3   N1x N    21.3729  -15.9550
            4   N1y N    19.1015  -15.9329
            5   O5x O    18.6308  -18.4135
            6   C5x C    20.2356  -15.1090
            7   C1a C    17.7859  -15.4541
            8   O5x O    20.2300  -13.6917
            9   C8y C    22.2941  -17.2706
            10  C8x C    22.9937  -18.4823
            11  C8x C    24.3937  -18.4824
            12  C8x C    25.0937  -17.2699
            13  C8x C    24.3941  -16.0582
            14  C8x C    22.9941  -16.0581
            15  C1b C    20.8941  -18.6706
            16  C1a C    19.6477  -19.3902
BOND        17
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 2
            8     4   6 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16    1  15 1
            17   15  16 1

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