| Entry |
|
|---|
| Name |
Ritonavir (JAN/USP/INN);
Norvir (TN) |
|---|
| Abbr |
RTV |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C37H48N6O5S2
|
|---|
| Exact mass |
720.3128
|
|---|
| Mol weight |
720.9442
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A inhibitor
Metabolizing enzyme inducer
DG01637 CYP1A2 inducer
DG02886 CYP2C9 inducer
DG02885 CYP2C19 inducer
|
|---|
| Remark |
| Therapeutic category: | 6250 |
| Product (mixture): | D02498<JP/US> D10582<US> |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Metabolism |
|
|---|
| Interaction |
CYP induction: CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557]
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
|
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| Structure map |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE03 Ritonavir
D00427 Ritonavir (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors (PI)
Ritonavir
D00427 Ritonavir (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D00427 Ritonavir (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00427
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00427
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 50
1 C1c C 33.1164 -17.1963
2 C1b C 33.1237 -18.5903
3 C1b C 34.3298 -16.5030
4 N1b N 31.9103 -16.5103
5 C8y C 34.1059 -19.5798
6 C1c C 35.5358 -17.1892
7 C5a C 30.7041 -17.2037
8 C8x C 33.3982 -20.7786
9 C8x C 35.4926 -19.5868
10 C1c C 36.7348 -16.4960
11 O1a O 35.5431 -18.5831
12 C1c C 29.4983 -16.5175
13 O5a O 30.7041 -18.5975
14 C8x C 34.0915 -21.9846
15 C8x C 36.1859 -20.7931
16 C1b C 36.7348 -15.0948
17 N1b N 37.9408 -17.1819
18 N1b N 28.2849 -17.2108
19 C1c C 29.4909 -14.6983
20 C8x C 35.4782 -21.9919
21 C8y C 35.5212 -14.3942
22 C7a C 39.1540 -16.4886
23 C5a C 27.0787 -16.5247
24 C1a C 30.7041 -13.9977
25 C1a C 28.2776 -13.9977
26 C8x C 35.5212 -13.0004
27 C8x C 34.3225 -15.1019
28 O7a O 40.3603 -17.1748
29 O6a O 39.1465 -15.0875
30 N1c N 25.8799 -17.2181
31 O5a O 27.0787 -15.1237
32 C8x C 34.3153 -12.3071
33 C8x C 33.1092 -14.4013
34 C1b C 41.5663 -16.4815
35 C1b C 24.6737 -16.5321
36 C1a C 25.8799 -18.6120
37 C8x C 33.1092 -13.0075
38 C8y C 42.7723 -17.1675
39 C8y C 23.4604 -17.2252
40 C8x C 42.7653 -18.5615
41 S2x S 44.1013 -16.7485
42 N5x N 22.1171 -16.8642
43 C8x C 23.4626 -18.6191
44 N5x N 44.0868 -18.9947
45 C8x C 44.9100 -17.8754
46 C8y C 21.3445 -18.0341
47 S2x S 22.2256 -19.1175
48 C1c C 19.9506 -18.0296
49 C1a C 19.1994 -16.8594
50 C1a C 19.3149 -19.2789
BOND 53
1 1 2 1 #Down
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 6 11 1 #Up
11 7 12 1
12 7 13 2
13 8 14 1
14 9 15 2
15 10 16 1 #Down
16 10 17 1
17 12 18 1
18 12 19 1 #Up
19 14 20 2
20 16 21 1
21 17 22 1
22 18 23 1
23 19 24 1
24 19 25 1
25 21 26 2
26 21 27 1
27 22 28 1
28 22 29 2
29 23 30 1
30 23 31 2
31 26 32 1
32 27 33 2
33 28 34 1
34 30 35 1
35 30 36 1
36 32 37 2
37 34 38 1
38 35 39 1
39 38 40 2
40 38 41 1
41 39 42 1
42 39 43 2
43 40 44 1
44 41 45 1
45 42 46 2
46 43 47 1
47 46 48 1
48 48 49 1
49 48 50 1
50 15 20 1
51 33 37 1
52 44 45 2
53 46 47 1
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