KEGG   DRUG: Sulfadiazine, silver
Entry
D00433                      Drug                                   

Name
Sulfadiazine, silver (USP);
Sulfadiazine silver (JP17);
Silvadene (TN)
Product
SILVER SULFADIAZINE (A-S Medication Solutions), SILVER SULFADIAZINE (A-S Medication Solutions), SILVADENE (A-S Medication Solutions), SILVER SULFADIAZINE (A-S Medication Solutions), SILVER SULFADIAZINE (A-S Medication Solutions), SILVER SULFADIAZINE (Ascend Laboratories), SILVER SULFADIAZINE (DIRECT RX), SSD CREAM (Dr Reddys Laboratories), SSD CREAM (Lake Erie Medical DBA Quality Care Products LLC), SILVER SULFADIAZINE (Medsource Pharmaceuticals), SILVER SULFADIAZINE (NuCare Pharmaceuticals), SILVER SULFADIAZINE (NuCare Pharmaceuticals), SILVER SULFADIAZINE (NuCare Pharmaceuticals), SILVADENE (Pfizer Laboratories Div Pfizer), THERMAZENE (Preferred Pharmaceuticals), SILVER SULFADIAZINE (Proficient Rx LP), SSD CREAM (REMEDYREPACK), SILVER SULFADIAZINE (REMEDYREPACK), SILVER SULFADIAZINE (REMEDYREPACK), SILVER SULFADIAZINE (RPK Pharmaceuticals)
  Generic
Formula
C10H9N4O2S. Ag
Exact mass
355.9497
Mol weight
357.1373
Structure
Simcomp
Class
Antibacterial
 DG01787  Sulfonamide antibacterial
  DG01785  Intermediate-acting sulfonamide
Remark
Therapeutic category: 2633
ATC code: D06BA01 J01EC02
Chemical structure group: DG00599
Product (DG00599): D00587<US> D00433<JP/US>
Efficacy
Antibacterial (topical), Folic acid biosynthesis inhibitor
Comment
Sulfonamide
Target
dihydropteroate synthase [KO:K00796]
  Pathway
ko00790  Folate biosynthesis
Interaction
Structure map
map07016  Sulfonamide derivatives - sulfa drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
    D06BA Sulfonamides
     D06BA01 Silver sulfadiazine
      D00433  Sulfadiazine, silver (USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01E SULFONAMIDES AND TRIMETHOPRIM
    J01EC Intermediate-acting sulfonamides
     J01EC02 Sulfadiazine
      D00433  Sulfadiazine, silver (USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Sulfonamides
   Sulfadiazine
    D00433  Sulfadiazine, silver (USP)
 Dermatological Agents
  Dermatological Agents, Other
   Wound Care Agents
    Silver Sulfadiazine
     D00433  Sulfadiazine, silver (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   263  Suppurative dermatosis agents
    2633  Sulfa drugs for external use
     D00433  Sulfadiazine, silver (USP); Sulfadiazine silver (JP17)
Antiinfectives [BR:br08307]
 Antibacterials
  Folic acid biosynthesis inhibitor
   Intermediate-acting sulfonamide
    D00433  Sulfadiazine, silver (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00433  Sulfadiazine silver
Other DBs
CAS: 22199-08-2
PubChem: 7847499
ChEBI: 9142
ChEMBL: CHEMBL1382627
DrugBank: DB05245
LigandBox: D00433
NIKKAJI: J550.743J
KCF data

ATOM        18
            1   C8y C    24.2684  -17.0689
            2   S4a S    25.4787  -16.3673
            3   C8x C    24.2741  -18.4665
            4   C8x C    23.0638  -16.3673
            5   N1b N    26.6891  -17.0689 #-
            6   O3c O    26.4610  -15.3792
            7   O3c O    24.4788  -15.3792
            8   C8x C    23.0638  -19.1682
            9   C8x C    21.8534  -17.0572
            10  C8y C    27.9052  -16.3673
            11  C8y C    21.8477  -18.4665
            12  N5x N    27.8995  -14.9639
            13  N5x N    29.1097  -17.0689
            14  N1a N    20.6373  -19.1622
            15  C8x C    29.1097  -14.2623
            16  C8x C    30.3200  -16.3732
            17  C8x C    30.3259  -14.9639
            18  Z   Ag   26.6605  -18.9740 #+
BOND        18
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     2   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    8  11 2
            11   10  12 2
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 2
            16   15  17 2
            17    9  11 1
            18   16  17 1

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