 | | DRUG: Ofloxacin | |
| Entry |
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| Name |
Ofloxacin (JP18/USP/INN);
Floxin (TN) |
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| Product |
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| Generic |
OFLOXACIN (A-S Medication Solutions), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (Akorn), OFLOXACIN (Akorn), OFLOXACIN (Amneal Pharmaceuticals NY LLC), OFLOXACIN (Apotex Corp.), OFLOXACIN (Bausch & Lomb Incorporated), OFLOXACIN (Bausch & Lomb Incorporated), OFLOXACIN (Cadila Pharmaceuticals Limited), OFLOXACIN (Dr. Reddy's Laboratories Limited), OFLOXACIN (Henry Schein), OFLOXACIN (Larken Laboratories), OFLOXACIN (Lifestar Pharma LLC), OFLOXACIN (Lifestar Pharma LLC), OFLOXACIN (MWI), OFLOXACIN (Nivagen Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (Rising Pharmaceuticals), OFLOXACIN (Rising Pharmaceuticals), OFLOXACIN OPHTHALMIC (Altaire Pharmaceuticals), OFLOXACIN OTIC (Apotex Corp.), OFLOXACIN OTIC (Bryant Ranch Prepack), OFLOXACIN OTIC (DIRECT RX), OFLOXACIN OTIC (Proficient Rx LP) |
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| Formula |
C18H20FN3O4
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| Exact mass |
361.1438
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| Mol weight |
361.3675
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| Structure |
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| Simcomp |
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| Class |
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00616): | D00453<JP/US> |
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| Efficacy |
Antibacterial, Nucleic acid biosynthesis inhibitor |
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| Target |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01M QUINOLONE ANTIBACTERIALS
J01MA Fluoroquinolones
J01MA01 Ofloxacin
D00453 Ofloxacin (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AE Fluoroquinolones
S01AE01 Ofloxacin
D00453 Ofloxacin (JP18/USP/INN) <JP/US>
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA16 Ofloxacin
D00453 Ofloxacin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Quinolones
Ofloxacin
D00453 Ofloxacin (JP18/USP/INN)
Ophthalmic Agents
Ophthalmic Anti-Infectives
Antibacterials, Ophthalmic
Ofloxacin
D00453 Ofloxacin (JP18/USP/INN)
Otic Agents
Otic Anti-Infectives
Ofloxacin
D00453 Ofloxacin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00453 Ofloxacin (JP18/USP/INN)
132 Otic and nasal agents
1329 Others
D00453 Ofloxacin (JP18/USP/INN)
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
624 Synthetic antibacterials
6241 Pyridonecarboxylic acids
D00453 Ofloxacin (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
DG00616 Ofloxacin
D00453 Ofloxacin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00616 Ofloxacin
D00453 Ofloxacin
Drug classes [BR:br08332]
Antibacterial
DG01549 Fluoroquinolone
D00453 Ofloxacin
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Fluoroquinolone
D00453 Ofloxacin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00453 Ofloxacin
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00453
Drug groups [BR:br08330]
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
DG00616 Ofloxacin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00616 Ofloxacin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Fluoroquinolone
DG00616 Ofloxacin
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| Other DBs |
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| KCF data |
ATOM 26
1 C8y C 23.3739 -16.5390
2 C8y C 22.1610 -17.2388
3 C8y C 23.3739 -15.1396
4 N4y N 24.5867 -17.2388
5 C8y C 20.9481 -16.5390
6 O2x O 22.1610 -18.6382
7 C8y C 24.5867 -14.4398
8 C8x C 22.1610 -14.4398
9 C8x C 25.7996 -16.5390
10 C1y C 24.5867 -18.6382
11 N1y N 19.7353 -17.2388
12 C8y C 20.9481 -15.1396
13 C1x C 23.3739 -19.3379
14 C8y C 25.7996 -15.1396
15 O5x O 24.5867 -13.0404
16 C1a C 25.7996 -19.3379
17 C1x C 18.5224 -16.5390
18 C1x C 19.7353 -18.6382
19 X F 19.7353 -14.4398
20 C6a C 27.0125 -14.4398
21 C1x C 17.3095 -17.2388
22 C1x C 18.5224 -19.3379
23 O6a O 27.0125 -13.0404
24 O6a O 28.2253 -15.1396
25 N1y N 17.3095 -18.6382
26 C1a C 16.0967 -19.3379
BOND 29
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 1
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 10 16 1
16 11 17 1
17 11 18 1
18 12 19 1
19 14 20 1
20 17 21 1
21 18 22 1
22 20 23 2
23 20 24 1
24 21 25 1
25 25 26 1
26 8 12 2
27 9 14 2
28 10 13 1
29 22 25 1
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