KEGG   DRUG: Ofloxacin
Entry
D00453                      Drug                                   
Name
Ofloxacin (JP18/USP/INN);
Floxin (TN)
Product
  Generic
Formula
C18H20FN3O4
Exact mass
361.1438
Mol weight
361.3675
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07321
Therapeutic category: 1319 1329 6241
ATC code: J01MA01 S01AE01 S02AA16
Chemical structure group: DG00616
Product (DG00616): D00453<JP/US>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Target
DNA gyrase [KO:K02469 K02470]
topoisomerase IV [KO:K02621 K02622]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07014  Quinolones
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA01 Ofloxacin
      D00453  Ofloxacin (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE01 Ofloxacin
      D00453  Ofloxacin (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA16 Ofloxacin
      D00453  Ofloxacin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ofloxacin
    D00453  Ofloxacin (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Ofloxacin
     D00453  Ofloxacin (JP18/USP/INN)
 Otic Agents
  Otic Anti-Infectives
   Ofloxacin
    D00453  Ofloxacin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00453  Ofloxacin (JP18/USP/INN)
   132  Otic and nasal agents
    1329  Others
     D00453  Ofloxacin (JP18/USP/INN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00453  Ofloxacin (JP18/USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00616  Ofloxacin
     D00453  Ofloxacin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00616  Ofloxacin
     D00453  Ofloxacin
Drug classes [BR:br08332]
 Antibacterial
  DG01549  Fluoroquinolone
   D00453  Ofloxacin
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D00453  Ofloxacin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00453  Ofloxacin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00453
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00616  Ofloxacin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00616  Ofloxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00616  Ofloxacin
Other DBs
CAS: 82419-36-1
PubChem: 7847519
ChEBI: 7731
LigandBox: D00453
NIKKAJI: J244.886F
KCF data

ATOM        26
            1   C8y C    23.3739  -16.5390
            2   C8y C    22.1610  -17.2388
            3   C8y C    23.3739  -15.1396
            4   N4y N    24.5867  -17.2388
            5   C8y C    20.9481  -16.5390
            6   O2x O    22.1610  -18.6382
            7   C8y C    24.5867  -14.4398
            8   C8x C    22.1610  -14.4398
            9   C8x C    25.7996  -16.5390
            10  C1y C    24.5867  -18.6382
            11  N1y N    19.7353  -17.2388
            12  C8y C    20.9481  -15.1396
            13  C1x C    23.3739  -19.3379
            14  C8y C    25.7996  -15.1396
            15  O5x O    24.5867  -13.0404
            16  C1a C    25.7996  -19.3379
            17  C1x C    18.5224  -16.5390
            18  C1x C    19.7353  -18.6382
            19  X   F    19.7353  -14.4398
            20  C6a C    27.0125  -14.4398
            21  C1x C    17.3095  -17.2388
            22  C1x C    18.5224  -19.3379
            23  O6a O    27.0125  -13.0404
            24  O6a O    28.2253  -15.1396
            25  N1y N    17.3095  -18.6382
            26  C1a C    16.0967  -19.3379
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15   10  16 1
            16   11  17 1
            17   11  18 1
            18   12  19 1
            19   14  20 1
            20   17  21 1
            21   18  22 1
            22   20  23 2
            23   20  24 1
            24   21  25 1
            25   25  26 1
            26    8  12 2
            27    9  14 2
            28   10  13 1
            29   22  25 1

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