KEGG   DRUG: Propoxyphene hydrochlorideHelp
Entry
D00482                      Drug                                   

Name
Propoxyphene hydrochloride (USAN);
Dextropropoxyphene hydrochloride;
Darvon (TN)
Product
  Generic
Formula
C22H29NO2. HCl
Exact mass
375.1965
Mol weight
375.9321
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
ATC code: N02AC04
Chemical structure group: DG00818
Product (DG00818): D00482<US>
Efficacy
Analgesic, Opioid receptor agonist
Comment
Diphenylpropylamine derivative
Propoxyphene is called Dextropropoxyphene in INN.
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AC Diphenylpropylamine derivatives
     N02AC04 Dextropropoxyphene
      D00482  Propoxyphene hydrochloride (USAN) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00482  Propoxyphene hydrochloride (USAN) <US>
BRITE hierarchy
Other DBs
CAS: 1639-60-7
PubChem: 7847548
ChEBI: 8498
ChEMBL: CHEMBL1237104 CHEMBL1864323
DrugBank: DB00647
LigandBox: D00482
NIKKAJI: J388.905J
KCF data Show

ATOM        26
            1   X   Cl   23.9038  -16.2708
            2   C8x C    14.7259  -19.2286
            3   C8x C    15.4238  -20.4397
            4   C8x C    16.8216  -20.4408
            5   C8x C    17.5215  -19.2309
            6   C8y C    16.8236  -18.0198
            7   C8x C    15.4258  -18.0187
            8   C8x C    18.9192  -19.2320
            9   C8y C    19.6191  -18.0220
            10  C1b C    18.9211  -16.8109
            11  C1d C    17.5234  -16.8098
            12  C8x C    19.6171  -20.4430
            13  C8x C    21.0149  -20.4441
            14  C8x C    21.7148  -19.2342
            15  C8x C    21.0169  -18.0231
            16  O7a O    16.8395  -15.6226
            17  C7a C    15.4474  -15.6215
            18  O6a O    14.7386  -16.8466
            19  C1b C    14.7583  -14.4256
            20  C1a C    13.3509  -14.4243
            21  C1c C    18.2223  -15.5994
            22  C1a C    19.6403  -15.5998
            23  C1b C    17.5168  -14.3775
            24  N1c N    18.2193  -13.1601
            25  C1a C    19.6402  -13.1603
            26  C1a C    17.5113  -11.9347
BOND        26
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9    11  10 1 #Down
            10   11   6 1 #Up
            11    8  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15    9  15 2
            16   11  16 1
            17   16  17 1
            18   17  18 2
            19   17  19 1
            20   19  20 1
            21   11  21 1
            22   21  22 1 #Up
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   24  26 1

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