KEGG   DRUG: Metoprolol tartrateHelp
Entry
D00601                      Drug                                   

Name
Metoprolol tartrate (JP17/USP);
Lopressor (TN)
Product
  Generic
METOPROLOL TARTRATE (Alembic Pharmaceuticals), METOPROLOL TARTRATE (Alembic Pharmaceuticals Limited), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTATE (Northwind Pharmaceuticals), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (ACETRIS HEALTH), METOPROLOL TARTRATE (Actavis Pharma), METOPROLOL TARTRATE (Advagen Pharma Limited), METOPROLOL TARTRATE (Aidarex Pharmaceuticals LLC), METOPROLOL TARTRATE (Alembic Pharmaceuticals Limited), METOPROLOL TARTRATE (Alvogen), METOPROLOL TARTRATE (American Health Packaging), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Apotheca), METOPROLOL TARTRATE (Athenex Pharmaceutical Division), METOPROLOL TARTRATE (Aurobindo Pharma Limited), METOPROLOL (Baxter Healthcare Corporation), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Cambridge Therapeutics Technologies), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL (Cardinal Health), METOPROLOL TARTRATE (Clinical Solutions Wholesale), METOPROLOL TARTRATE (Clinical Solutions Wholesale), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (DIRECT RX), METOPROLOL TARTRATE (DOH CENTRAL PHARMACY), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Fosun Pharma USA), METOPROLOL (Fresenius Kabi USA), METOPROLOL TARTRATE (General Injectables & Vaccines), METOPROLOL TARTRATE (Gland Pharma Limited), METOPROLOL TARTRATE (Hospira), METOPROLOL TARTRATE (Hospira), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Legacy Pharmaceutical Packaging), METOPROLOL TARTRATE (Major Pharmaceuticals), METOPROLOL TARTRATE (Medical Purchasin Solutions), METOPROLOL (Medical Purchasing Solutions), METOPROLOL TARTRATE (Mylan Institutional), METOPROLOL TARTRATE (Mylan Pharmaceuticals), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (Northwind Pharmaceuticals), METOPROLOL TARTRATE (Northwind Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (QPharma), METOPROLOL TARTRATE (QPharma), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (RPK Pharmaceuticals), METOPROLOL TARTRATE (RedPharm Drug), METOPROLOL TARTRATE (RedPharm Drug), METOPROLOL TARTRATE (RedPharm Drug), METOPROLOL TARTRATE (Rising Health), METOPROLOL TARTRATE (Safecor Health), METOPROLOL TARTRATE (Safecor Health), METOPROLOL TARTRATE (St Marys Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (State of Florida DOH Central Pharmacy), METOPROLOL TARTRATE (State of Florida DOH Central Pharmacy), METOPROLOL TARTRATE (State of Florida DOH Central Pharmacy), METOPROLOL TARTRATE (Sun Pharmaceutical Industries), METOPROLOL TARTRATE (TruPharma LLC), METOPROLOL TARTRATE (Unit Dose Services), METOPROLOL TARTRATE (Vensun Pharmaceuticals), METOPROLOL TARTRATE (West-Ward Pharmaceuticals Corp)
Formula
(C15H25NO3)2. C4H6O6
Exact mass
684.3833
Mol weight
684.8146
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 2123 2149
ATC code: C07AB02
Chemical structure group: DG00313
Product (DG00313): D00601<JP/US> D00635<US>
Product (mixture): D10273<US>
Efficacy
Antiarrhythmic, Antihypertensive, Vasodilator, beta1-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Angina pectoris [DS:H01632]
Myocardial infarction [DS:H01730]
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07048  Antimigraines
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB02 Metoprolol
      D00601  Metoprolol tartrate (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Metoprolol
    D00601  Metoprolol tartrate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00601  Metoprolol tartrate (JP17/USP)
   214  Antihypertensives
    2149  Others
     D00601  Metoprolol tartrate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB1
     D00601  Metoprolol tartrate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00601  Metoprolol tartrate
  D00601  Metoprolol tartrate tablets
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00601
BRITE hierarchy
Other DBs
CAS: 56392-17-7
PubChem: 7847667
ChEBI: 6906
ChEMBL: CHEMBL3186768
DrugBank: DB00264
LigandBox: D00601
NIKKAJI: J523.393C
KCF data Show

ATOM        48
            1   C1c C    28.6300  -22.7500
            2   C1c C    29.8900  -22.0500
            3   C6a C    27.4400  -22.0500
            4   O1a O    28.6300  -24.1500
            5   C6a C    31.0800  -22.7500
            6   O1a O    29.8900  -20.6500
            7   O6a O    26.2500  -22.7500
            8   O6a O    27.4400  -20.6500
            9   O6a O    32.2700  -22.0500
            10  O6a O    31.0800  -24.1500
            11  O2a O    14.6300  -19.8800
            12  C1b C    15.8200  -19.1800
            13  C1c C    17.0100  -19.8800
            14  C1b C    18.2000  -19.1800
            15  O1a O    17.0100  -21.2800
            16  N1b N    19.4600  -19.8800
            17  C1c C    20.6500  -19.1800
            18  C1a C    21.8400  -19.8800
            19  C1a C    20.6500  -17.8500
            20  C8y C    14.6300  -21.2800
            21  C8x C    13.4176  -21.9800
            22  C8x C    13.4176  -23.3800
            23  C8y C    14.6300  -24.0800
            24  C8x C    15.8424  -23.3800
            25  C8x C    15.8424  -21.9800
            26  C1b C    14.6300  -25.4800
            27  C1b C    13.4176  -26.1800
            28  O2a O    12.2221  -25.4896
            29  C1a C    11.0347  -26.1751
            30  O2a O    14.6300  -19.8800
            31  C1b C    15.8200  -19.1800
            32  C1c C    17.0100  -19.8800
            33  C1b C    18.2000  -19.1800
            34  N1b N    19.4600  -19.8800
            35  C1c C    20.6500  -19.1800
            36  C1a C    21.8400  -19.8800
            37  C1a C    20.6500  -17.8500
            38  O1a O    17.0100  -21.2800
            39  C8y C    14.6300  -21.2800
            40  C8x C    13.4176  -21.9800
            41  C8x C    13.4176  -23.3800
            42  C8y C    14.6300  -24.0800
            43  C8x C    15.8424  -23.3800
            44  C8x C    15.8424  -21.9800
            45  C1b C    14.6300  -25.4800
            46  C1b C    13.4176  -26.1800
            47  O2a O    12.2221  -25.4896
            48  C1a C    11.0347  -26.1751
BOND        47
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 2
            8     5   9 1
            9     5  10 2
            10   11  12 1
            11   12  13 1
            12   13  14 1
            13   13  15 1
            14   14  16 1
            15   16  17 1
            16   17  18 1
            17   17  19 1
            18   11  20 1
            19   20  21 2
            20   21  22 1
            21   22  23 2
            22   23  24 1
            23   24  25 2
            24   20  25 1
            25   23  26 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   30  31 1
            30   31  32 1
            31   32  33 1
            32   32  38 1
            33   33  34 1
            34   34  35 1
            35   35  36 1
            36   35  37 1
            37   30  39 1
            38   39  40 2
            39   40  41 1
            40   41  42 2
            41   42  43 1
            42   43  44 2
            43   39  44 1
            44   42  45 1
            45   45  46 1
            46   46  47 1
            47   47  48 1
BRACKET     1     8.7500  -26.9500    8.7500  -16.5900
            1    23.7300  -16.5900   23.7300  -26.9500
            1  2
 ORIGINAL  1   11  12  13  14  16  17  18  19  15  20  21  22  23  24  25  26
            1   27  28  29
 REPEAT    1   30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45
            1   46  47  48

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