| Entry |
|
|---|
| Name |
Dopamine hydrochloride (JP17/USP);
Actopamin (TN);
Intropin (TN)
|
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| Product |
|
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| Generic |
|
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| Formula |
C8H11NO2. HCl
|
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| Exact mass |
189.0557
|
|---|
| Mol weight |
189.6394
|
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| Structure |
   |
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| Simcomp |
 |
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| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG01592 COMT substrate
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01467 Dopamine D1-receptor agonist
DG01468 Dopamine D2-receptor agonist
DG01469 Dopamine D3-receptor agonist
DG01470 Dopamine D4-receptor agonist
DG01471 Dopamine D5-receptor agonist
Metabolizing enzyme substrate
DG02917 MAO substrate
Transporter substrate
DG02854 SLC22A2 (OCT2) substrate
|
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| Remark |
| Therapeutic category: | 2119 |
| Product (DG00213): | D00633<JP/US> |
|
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| Efficacy |
Cardiotonic, Dopamine receptor agonist |
|---|
| Disease |
Myocardial infarction [DS: H01730] |
|---|
| Comment |
Catecholamine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: MAOB [HSA: 4129], COMT [HSA: 1312]
Transporter: SLC22A2 [HSA: 6582]
|
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| Interaction |
|
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| Structure map |
| map07213 | Dopamine receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA04 Dopamine
D00633 Dopamine hydrochloride (JP17/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
211 Cardiotonics
2119 Others
D00633 Dopamine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD
D00633 Dopamine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00633 Dopamine hydrochloride
D00633 Dopamine hydrochloride injection
 |
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| Other DBs |
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| KCF data |
ATOM 12
1 C8y C 28.7000 -14.7000
2 C8x C 27.5100 -14.0000
3 C8x C 28.7000 -16.1000
4 C1b C 29.8900 -14.0000
5 C8y C 26.3200 -14.7000
6 C8x C 27.5100 -16.8000
7 C1b C 31.1500 -14.7000
8 C8y C 26.3200 -16.1000
9 O1a O 25.0600 -14.0000
10 N1a N 32.3400 -14.0000
11 O1a O 25.0600 -16.8000
12 X Cl 32.5500 -16.8000
BOND 11
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 4 7 1
7 5 8 1
8 5 9 1
9 7 10 1
10 8 11 1
11 6 8 2
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