KEGG   DRUG: Loperamide hydrochlorideHelp
Entry
D00729                      Drug                                   

Name
Loperamide hydrochloride (JAN/USP);
Imodium (TN)
Product
  Generic
LOPERAMIDE HYDROCHLORIDE (A-S Medication Solutions), LOPERAMIDE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), LOPERAMIDE HYDROCHLORIDE (American Health Packaging), LOPERAMIDE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), LOPERAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), LOPERAMIDE HYDROCHLORIDE (Cardinal Health), LOPERAMIDE HYDROCHLORIDE (Cardinal Health), LOPERAMIDE HYDROCHLORIDE (Contract Pharmacy Services-PA), LOPERAMIDE HYDROCHLORIDE (Contract Pharmacy Services-PA), LOPERAMIDE HYDROCHLORIDE (Mylan Institutional), LOPERAMIDE HYDROCHLORIDE (Mylan Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NCS HealthCare of KY), LOPERAMIDE HYDROCHLORIDE (Northwind Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (NuCare pharmceuticals), LOPERAMIDE HYDROCHLORIDE (PD-Rx Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (PD-Rx Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (Preferred Pharmaceuticals), LOPERAMIDE HYDROCHLORIDE (QPharma), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (REMEDYREPACK), LOPERAMIDE HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C29H33ClN2O2. HCl
Exact mass
512.1997
Mol weight
513.4985
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Anti-allergic agent
 DG01957  Antidiarrheal
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 (P-GP) substrate
Remark
Therapeutic category: 2319
ATC code: A07DA03
Chemical structure group: DG00092
Product (DG00092): D00729<JP/US>
Efficacy
Antidiarrheal, Antiperistaltic, Opioid receptor agonist
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRD1 [HSA:4985] [KO:K04213]
OPRK1 [HSA:4986] [KO:K04214]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C8 [HSA:1558]
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07D ANTIPROPULSIVES
    A07DA Antipropulsives
     A07DA03 Loperamide
      D00729  Loperamide hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Anti-Diarrheal Agents
   Loperamide
    D00729  Loperamide hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   231  Antidiarrheals, intestinal regulators
    2319  others
     D00729  Loperamide hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  16 Antidiarrheals
   D00729  Loperamide hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Loperamide
    D00729  Loperamide hydrochloride (JAN/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Loperamide
    D00729  Loperamide hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00729  Loperamide hydrochloride (JAN/USP) <JP/US>
    OPRK1
     D00729  Loperamide hydrochloride (JAN/USP) <JP/US>
    OPRD1
     D00729  Loperamide hydrochloride (JAN/USP) <JP/US>
Rx-to-OTC switch list in Japan [br08314.html]
 D00729
BRITE hierarchy
Other DBs
CAS: 34552-83-5
PubChem: 7847794
ChEBI: 6533
ChEMBL: CHEMBL1707
DrugBank: DB00836
LigandBox: D00729
NIKKAJI: J262.733G
KCF data Show

ATOM        35
            1   X   Cl   36.9600  -15.4700
            2   C8x C    28.0700  -18.6900
            3   C8x C    28.0700  -20.0200
            4   C8x C    29.2600  -20.7200
            5   C8x C    30.4500  -20.0200
            6   C8y C    30.4500  -18.6900
            7   C8x C    29.2600  -18.0600
            8   C8x C    32.7600  -20.0200
            9   C8y C    32.7600  -18.6900
            10  C1d C    31.5700  -18.0600
            11  C8x C    33.9500  -20.7200
            12  C8x C    35.0700  -20.0200
            13  C8x C    35.0700  -18.6900
            14  C8x C    33.9500  -18.0600
            15  C5a C    28.3500  -16.3800
            16  N1c N    27.2300  -17.0800
            17  O5a O    28.3500  -15.0500
            18  C1b C    31.5700  -16.6600
            19  C1b C    32.8300  -15.9600
            20  N1y N    32.8300  -14.5600
            21  C1x C    34.0200  -13.8600
            22  C1x C    34.0200  -12.4600
            23  C1z C    32.8300  -11.7600
            24  C1x C    31.5700  -12.4600
            25  C1x C    31.5700  -13.8600
            26  C1a C    25.9938  -16.4229
            27  C1a C    27.2090  -18.4791
            28  C8y C    32.8472  -10.3601
            29  C8x C    34.0551   -9.6824
            30  C8x C    34.0722   -8.2825
            31  C8y C    32.8684   -7.5677
            32  C8x C    31.6606   -8.2454
            33  C8x C    31.6435   -9.6453
            34  O1a O    34.0424  -11.0600
            35  X   Cl   32.8855   -6.1601
BOND        37
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14    9  14 2
            15   10  15 1
            16   15  16 1
            17   15  17 2
            18   10  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   20  25 1
            27   16  26 1
            28   16  27 1
            29   23  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   31  32 1
            34   32  33 2
            35   28  33 1
            36   23  34 1
            37   31  35 1

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