KEGG   DRUG: Interferon beta-1bHelp
Entry
D00746                      Drug                                   

Name
Interferon beta-1b (USAN/INN);
Interferon beta-1b (genetical recombination) (JAN);
Betaseron (TN);
Extavia (TN)
Product
Formula
C903H1399N245O252S5
Exact mass
19867.2792
Mol weight
19879.5855
Sequence
SYNLLGFLQR SSNFQSQKLL WQLNGRLEYC LKDRMNFDIP EEIKQLQQFQ KEDAALTIYE
MLQNIFAIFR QDSSSTGWNE TIVENLLANV YHQINHLKTV LEEKLEKEDF TRGKLMSSLH
LKRYYGRILH YLKAKEYSHC AWTIVRVEIL RNFYFINRLT GYLRN
  Type
Peptide
Class
Antineoplastic
 DG01752  Interferone
Remark
Therapeutic category: 6399
ATC code: L03AB08
Chemical structure group: DG01751
Product (DG01751): D00746<JP/US> D03304<JP> D04554<JP/US>
Efficacy
Immunomodulator, Biological response modifier
  Disease
Multiple sclerosis [DS:H01490]
Target
IFNAR1 [HSA:3454] [KO:K05130]
IFNAR2 [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB08 Interferon beta-1b
      D00746  Interferon beta-1b (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Interferon beta-1b
    D00746  Interferon beta-1b (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D00746  Interferon beta-1b (USAN/INN); Interferon beta-1b (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interferon receptors
    IFNAR1
     D00746  Interferon beta-1b (USAN/INN) <JP/US>
    IFNAR2
     D00746  Interferon beta-1b (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00746
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00746
BRITE hierarchy
Other DBs
CAS: 145155-23-3
PubChem: 7847811
ChEBI: 5938
DrugBank: DB00068

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