KEGG   DRUG: AldesleukinHelp
Entry
D00748                      Drug                                   

Name
Aldesleukin (USAN/INN);
Interleukin-2;
Proleukin (TN)
Product
Formula
C690H1115N177O203S6
Exact mass
15321.0691
Mol weight
15330.6902
Sequence
Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu
Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn
Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys
Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro
Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg
Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys
Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr
Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile
Ser Thr Leu Thr
  Type
Peptide
Remark
Same as: C07903
ATC code: L03AC01
Product: D00748<US>
Efficacy
Antineoplastic, Immunostimulant, Biological response modifier
  Disease
Renal cell carcinoma [DS:H00021]
Melanoma [DS:H00038]
Comment
human recombinant interleukin-2 product
Target
IL2RA (CD25) [HSA:3559] [KO:K05068]
IL2RB (CD122) [HSA:3560] [KO:K05069]
IL2RG (CD132) [HSA:3561] [KO:K05070]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05200  Pathways in cancer
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AC Interleukins
     L03AC01 Aldesleukin
      D00748  Aldesleukin (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL2RA (CD25)
     D00748  Aldesleukin (USAN/INN) <US>
    IL2RB (CD122)
     D00748  Aldesleukin (USAN/INN) <US>
    IL2RG (CD132)
     D00748  Aldesleukin (USAN/INN) <US>
Antineoplastics [br08340.html]
 D00748
BRITE hierarchy
Other DBs
CAS: 110942-02-4
PubChem: 7847813
DrugBank: DB00041

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