KEGG   DRUG: Chlorpromazine hydrochlorideHelp
Entry
D00789                      Drug                                   

Name
Chlorpromazine hydrochloride (JP17/USP);
Sonazine (TN)
Product
  Generic
CHLORPROMAZINE HCI (HF Acquisition Co LLC), CHLORPROMAZINE HYDROCHLORIDE (A-S Medication Solutions), CHLORPROMAZINE HYDROCHLORIDE (American Health Packaging), CHLORPROMAZINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), CHLORPROMAZINE HYDROCHLORIDE (Carilion Materials Management), CHLORPROMAZINE HYDROCHLORIDE (DOH CENTRAL PHARMACY), CHLORPROMAZINE HYDROCHLORIDE (General Injectables and Vaccines), CHLORPROMAZINE HYDROCHLORIDE (Major Pharmaceuticals), CHLORPROMAZINE HYDROCHLORIDE (Mylan Institutional), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (Sandoz), CHLORPROMAZINE HYDROCHLORIDE (Upsher-Smith Laboratories), CHLORPROMAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
Formula
C17H19ClN2S. HCl
Exact mass
354.0724
Mol weight
355.3251
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG01491  Muscarinic cholinergic receptor antagonist
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07952
Therapeutic category: 1171
ATC code: N05AA01
Chemical structure group: DG00867
Product (DG00867): D00789<JP/US> D04034<JP>
Efficacy
Anti-emetic, Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Acute intermittent porphyria [DS:H00202 H01763]
Tetanus [DS:H00337]
Manic-depressive illness [DS:H01653]
Comment
Phenothiazine derivative
Target
HTR2 [HSA:3356 3357 3358] [KO:K04157]
HRH1 [HSA:3269] [KO:K04149]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
DRD2 [HSA:1813] [KO:K04145]
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA01 Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Chlorpromazine
    D00789  Chlorpromazine hydrochloride (JP17/USP)
 Antipsychotics
  1st Generation/Typical
   Chlorpromazine
    D00789  Chlorpromazine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1171  Chlorpromazines
     D00789  Chlorpromazine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00789  Chlorpromazine hydrochloride (JP17/USP) <JP/US>
   Adrenaline
    ADRA2
     D00789  Chlorpromazine hydrochloride (JP17/USP) <JP/US>
   Dopamine
    DRD2
     D00789  Chlorpromazine hydrochloride (JP17/USP) <JP/US>
   Histamine
    HRH1
     D00789  Chlorpromazine hydrochloride (JP17/USP) <JP/US>
   Serotonin
    HTR2
     D00789  Chlorpromazine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00789  Chlorpromazine hydrochloride
  D00789  Chlorpromazine hydrochloride tablets
  D00789  Chlorpromazine hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 69-09-0
PubChem: 7847854
ChEBI: 3649
ChEMBL: CHEMBL1713
DrugBank: DB00477
LigandBox: D00789
NIKKAJI: J237.634B
KCF data Show

ATOM        22
            1   C8x C    22.8265  -17.0415
            2   C8x C    22.8265  -18.4441
            3   C8x C    24.0411  -19.1454
            4   C8y C    25.2559  -18.4441
            5   C8y C    25.2559  -17.0415
            6   C8x C    24.0411  -16.3402
            7   S2x S    26.4706  -19.1454
            8   C8y C    27.6853  -18.4441
            9   C8y C    27.6853  -17.0415
            10  N4y N    26.4706  -16.3402
            11  C8x C    28.9001  -19.1454
            12  C8x C    30.1147  -18.4441
            13  C8y C    30.1147  -17.0415
            14  C8x C    28.9001  -16.3402
            15  C1b C    26.4706  -14.9375
            16  C1b C    27.6874  -14.2350
            17  C1b C    28.8861  -14.9273
            18  N1c N    30.0752  -14.2408
            19  C1a C    31.2689  -14.9303
            20  C1a C    30.0754  -12.8338
            21  X   Cl   31.3335  -16.3379
            22  X   Cl   34.2300  -17.7100
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   13  21 1

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