| Entry |
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| Name |
Chlorpromazine hydrochloride (JP17/USP);
Sonazine (TN)
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| Product |
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| Generic |
CHLORPROMAZINE HCI (HF Acquisition Co LLC), CHLORPROMAZINE HYDROCHLORIDE (A-S Medication Solutions), CHLORPROMAZINE HYDROCHLORIDE (American Health Packaging), CHLORPROMAZINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), CHLORPROMAZINE HYDROCHLORIDE (Carilion Materials Management), CHLORPROMAZINE HYDROCHLORIDE (DOH CENTRAL PHARMACY), CHLORPROMAZINE HYDROCHLORIDE (General Injectables and Vaccines), CHLORPROMAZINE HYDROCHLORIDE (Major Pharmaceuticals), CHLORPROMAZINE HYDROCHLORIDE (Mylan Institutional), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (Sandoz), CHLORPROMAZINE HYDROCHLORIDE (Upsher-Smith Laboratories), CHLORPROMAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.) |
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| Formula |
C17H19ClN2S. HCl
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| Exact mass |
354.0724
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| Mol weight |
355.3251
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| Structure |
   |
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| Simcomp |
 |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01905 Phenothiazine antipsychotics
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG01491 Muscarinic cholinergic receptor antagonist
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
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| Remark |
| Therapeutic category: | 1171 |
| Product (DG00867): | D00789<JP/US> D04034<JP> |
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| Efficacy |
Anti-emetic, Antipsychotic |
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| Disease |
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| Comment |
Phenothiazine derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
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| Structure map |
| map07029 | Antipsychotics - phenothiazines |
| map07212 | Histamine H1 receptor antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AA Phenothiazines with aliphatic side-chain
N05AA01 Chlorpromazine
D00789 Chlorpromazine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Chlorpromazine
D00789 Chlorpromazine hydrochloride (JP17/USP)
Antipsychotics
1st Generation/Typical
Chlorpromazine
D00789 Chlorpromazine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1171 Chlorpromazines
D00789 Chlorpromazine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D00789 Chlorpromazine hydrochloride (JP17/USP) <JP/US>
Adrenaline
ADRA2
D00789 Chlorpromazine hydrochloride (JP17/USP) <JP/US>
Dopamine
DRD2
D00789 Chlorpromazine hydrochloride (JP17/USP) <JP/US>
Histamine
HRH1
D00789 Chlorpromazine hydrochloride (JP17/USP) <JP/US>
Serotonin
HTR2
D00789 Chlorpromazine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00789 Chlorpromazine hydrochloride
D00789 Chlorpromazine hydrochloride tablets
D00789 Chlorpromazine hydrochloride injection
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| Other DBs |
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| KCF data |
ATOM 22
1 C8x C 22.8265 -17.0415
2 C8x C 22.8265 -18.4441
3 C8x C 24.0411 -19.1454
4 C8y C 25.2559 -18.4441
5 C8y C 25.2559 -17.0415
6 C8x C 24.0411 -16.3402
7 S2x S 26.4706 -19.1454
8 C8y C 27.6853 -18.4441
9 C8y C 27.6853 -17.0415
10 N4y N 26.4706 -16.3402
11 C8x C 28.9001 -19.1454
12 C8x C 30.1147 -18.4441
13 C8y C 30.1147 -17.0415
14 C8x C 28.9001 -16.3402
15 C1b C 26.4706 -14.9375
16 C1b C 27.6874 -14.2350
17 C1b C 28.8861 -14.9273
18 N1c N 30.0752 -14.2408
19 C1a C 31.2689 -14.9303
20 C1a C 30.0754 -12.8338
21 X Cl 31.3335 -16.3379
22 X Cl 34.2300 -17.7100
BOND 23
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 1
23 13 21 1
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