| Entry |
|
|---|
| Name |
Leuprolide acetate (USP);
Leuprorelin acetate (JP18);
Lupron (TN);
Lutrate (TN);
Eligard (TN);
Fensolvi (TN) |
|---|
| Product |
|
|---|
| Generic |
LEUPROLIDE ACETATE (Amneal Pharmaceuticals LLC), LEUPROLIDE ACETATE (Avenacy), LEUPROLIDE ACETATE (Eugia US LLC), LEUPROLIDE ACETATE (Meitheal Pharmaceuticals), LEUPROLIDE ACETATE (NorthStar RxLLC), LEUPROLIDE ACETATE (PAI Holdings), LEUPROLIDE ACETATE (Sandoz), LEUPROLIDE ACETATE (Sun Pharmaceutical Industries), LEUPROLIDE ACETATE (UBI Pharma), LEUPROLIDE ACETATE (VGYAAN Pharmaceuticals LLC), LEUPROLIDE ACETATE (Zydus Lifesciences Limited), LEUPROLIDE ACETATE (Zydus Pharmaceuticals USA), VABRINTY (URONOVA PHARMACEUTICALS) |
|---|
| Formula |
C59H84N16O12. C2H4O2
|
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| Exact mass |
1268.6666
|
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| Mol weight |
1269.45
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
|
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| Remark |
| Therapeutic category: | 2499 |
| Product (DG00730): | D00989<JP/US> D12337<US> |
|
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| Efficacy |
Antineoplastic, Gonadotropin-releasing hormone receptor agonist |
|---|
| Disease |
Endometriosis [DS: H01639] Uterine leiomyomata [DS: H01640] Central precocious puberty [DS: H02018] Prostate cancer [DS: H00024] |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02A HORMONES AND RELATED AGENTS
L02AE Gonadotropin releasing hormone analogues
L02AE02 Leuprorelin
D00989 Leuprolide acetate (USP) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Antineoplastics, Other
Antineoplastics, Miscellaneous
Leuprolide
D00989 Leuprolide acetate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
249 Miscellaneous
2499 Others
D00989 Leuprolide acetate (USP); Leuprorelin acetate (JP18)
Drug groups [BR:br08330]
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
DG00730 Leuprorelin
D00989 Leuprolide acetate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Gonadotropin-releasing hormone
GNRHR
D00989 Leuprolide acetate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00989 Leuprorelin acetate
Drug groups [BR:br08330]
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
DG00730 Leuprorelin
|
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| Other DBs |
|
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| KCF data |
ATOM 91
1 C6a C 23.3263 -21.2463
2 C1a C 22.1044 -21.9542
3 O6a O 24.5383 -21.9443
4 O6a O 23.3164 -19.8402
5 C1c C 19.2124 -15.3004
6 N1b N 18.0037 -15.9403
7 C5a C 20.4211 -15.9403
8 C5a C 16.7951 -15.3004
9 N1b N 21.5587 -15.2293
10 O5a O 20.4211 -17.2911
11 C1c C 15.5864 -16.0114
12 O5a O 16.7951 -13.8784
13 C1c C 22.7673 -15.8692
14 N1b N 14.3777 -15.3004
15 C5a C 23.9760 -15.2293
16 C5a C 13.1691 -16.0114
17 N1b N 25.1847 -15.8692
18 O5a O 23.9760 -13.8073
19 C1y C 11.9604 -15.3715
20 O5a O 13.1691 -17.4333
21 C1c C 26.3933 -15.1582
22 C1x C 10.6806 -15.7981
23 N1x N 11.9604 -13.9495
24 C1b C 26.3933 -13.8073
25 C5a C 27.6020 -15.8692
26 C1x C 9.8986 -14.6605
27 C5x C 10.6806 -13.5940
28 C8y C 27.5309 -13.0963
29 N1b N 28.8107 -15.1582
30 O5a O 27.6020 -17.2911
31 O5x O 10.2540 -12.2432
32 C8x C 28.8107 -13.7362
33 C8x C 27.5309 -11.6744
34 C1c C 30.0904 -15.8692
35 C8x C 30.0193 -13.0252
36 C8x C 28.7396 -10.9634
37 C5a C 31.2991 -15.1582
38 C8y C 30.0193 -11.6744
39 N1b N 32.5078 -15.8692
40 O5a O 31.2991 -13.7362
41 O1a O 31.1569 -10.9634
42 C1c C 33.6453 -15.1582
43 C5a C 34.8540 -15.7981
44 N1b N 36.0627 -15.0871
45 O5a O 34.8540 -17.2200
46 C1c C 37.2714 -15.7981
47 C5a C 38.4800 -15.0871
48 C1b C 37.2714 -17.2200
49 N1y N 39.7598 -15.7270
50 O5a O 38.4800 -13.6651
51 C1y C 41.1107 -15.7270
52 C1x C 39.3332 -17.0778
53 C1x C 41.5372 -17.0778
54 C5a C 42.3904 -15.0160
55 C1x C 40.3997 -17.8599
56 N1b N 43.6702 -15.7981
57 O5a O 42.3904 -13.5229
58 C1b C 19.2124 -13.8784
59 C8y C 20.4922 -13.2385
60 C8y C 20.9188 -11.9588
61 C8x C 21.6298 -14.0206
62 C8y C 22.2696 -11.9588
63 C8x C 20.2078 -10.7501
64 N4x N 22.7673 -13.2385
65 C8x C 22.9806 -10.6790
66 C8x C 20.9188 -9.5414
67 C8x C 22.2696 -9.5414
68 C1b C 15.5864 -17.4333
69 C8y C 16.7951 -18.1443
70 C8x C 16.7951 -19.4952
71 N5x N 18.0748 -19.9929
72 C8x C 18.9280 -18.9264
73 N4x N 18.2170 -17.7177
74 C1b C 22.7673 -17.2911
75 O1a O 23.9987 -18.0021
76 C1b C 30.1079 -17.2910
77 C1c C 31.3348 -17.9794
78 C1a C 32.5730 -17.2436
79 C1a C 31.3521 -19.4240
80 C1b C 33.6655 -13.7371
81 C1c C 34.8918 -13.0520
82 C1a C 36.1253 -13.7879
83 C1a C 34.9118 -11.6034
84 C1b C 44.9105 -15.1025
85 C1a C 46.1028 -15.8110
86 C1b C 38.4988 -17.9379
87 C1b C 38.4988 -19.3599
88 N1b N 37.2564 -20.0774
89 C2c C 36.0305 -19.3696
90 N1a N 34.8305 -20.0625
91 N2a N 36.0300 -17.9314
BOND 95
1 1 2 1
2 1 3 1
3 1 4 2
4 5 6 1
5 5 7 1
6 6 8 1
7 7 9 1
8 7 10 2
9 8 11 1
10 8 12 2
11 9 13 1
12 11 14 1
13 13 15 1
14 14 16 1
15 15 17 1
16 15 18 2
17 16 19 1
18 16 20 2
19 17 21 1
20 19 22 1
21 19 23 1
22 21 24 1
23 21 25 1
24 22 26 1
25 23 27 1
26 24 28 1
27 25 29 1
28 25 30 2
29 27 31 2
30 28 32 2
31 28 33 1
32 29 34 1
33 32 35 1
34 33 36 2
35 34 37 1
36 35 38 2
37 37 39 1
38 37 40 2
39 38 41 1
40 39 42 1
41 42 43 1
42 43 44 1
43 43 45 2
44 44 46 1
45 46 47 1
46 46 48 1
47 47 49 1
48 47 50 2
49 49 51 1
50 49 52 1
51 51 53 1
52 51 54 1
53 52 55 1
54 54 56 1
55 54 57 2
56 26 27 1
57 36 38 1
58 53 55 1
59 5 58 1
60 58 59 1
61 59 60 1
62 60 62 2
63 60 63 1
64 61 64 1
65 62 65 1
66 63 66 2
67 65 67 2
68 62 64 1
69 66 67 1
70 61 59 2
71 11 68 1
72 68 69 1
73 69 70 2
74 70 71 1
75 71 72 2
76 72 73 1
77 73 69 1
78 13 74 1
79 74 75 1
80 34 76 1
81 76 77 1
82 77 78 1
83 77 79 1
84 42 80 1
85 80 81 1
86 81 82 1
87 81 83 1
88 56 84 1
89 84 85 1
90 48 86 1
91 86 87 1
92 87 88 1
93 88 89 1
94 89 90 1
95 89 91 2
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