KEGG   DRUG: Tolazoline hydrochlorideHelp
Entry
D00997                      Drug                                   

Name
Tolazoline hydrochloride (JAN/USP);
Priscoline (TN)
Formula
C10H12N2. HCl
Exact mass
196.0767
Mol weight
196.6766
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Remark
ATC code: C04AB02 M02AX02
Chemical structure group: DG00281
Efficacy
Vasodilator (peripheral), alpha-Adrenergic receptor antagonist
Comment
Imidazoline derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AB Imidazoline derivatives
     C04AB02 Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AX Other topical products for joint and muscular pain
     M02AX02 Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00997  Tolazoline hydrochloride (JAN/USP)
    ADRA2
     D00997  Tolazoline hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 59-97-2
PubChem: 7848060
ChEBI: 9615
ChEMBL: CHEMBL1689
DrugBank: DB00797
LigandBox: D00997
NIKKAJI: J231.280H
KCF data Show

ATOM        13
            1   X   Cl   18.6900  -23.3800
            2   C8x C    15.4700  -21.9800
            3   C8x C    15.4700  -23.3800
            4   C8x C    14.2800  -24.0800
            5   C8x C    13.0200  -23.3800
            6   C8x C    13.0200  -21.9800
            7   C8y C    14.2800  -21.2800
            8   C1b C    14.2800  -19.8800
            9   C2y C    15.4700  -19.1800
            10  N2x N    15.4700  -17.7800
            11  C1x C    16.8000  -17.3600
            12  C1x C    17.6400  -18.4800
            13  N1x N    16.8000  -19.6000
BOND        13
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    9  13 1

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