KEGG   DRUG: Neostigmine methylsulfate
Entry
D00998                      Drug                                   

Name
Neostigmine methylsulfate (JP17/USP);
Bloxiverz (TN);
Prostigmin (TN)
Product
  Generic
NEOSTIGMINE (Dr.Reddy's Laboratories), NEOSTIGMINE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (A-S Medication Solutions), NEOSTIGMINE METHYLSULFATE (A-S Medication Solutions), NEOSTIGMINE METHYLSULFATE (American Regent), NEOSTIGMINE METHYLSULFATE (Amneal Pharmaceuticals LLC), NEOSTIGMINE METHYLSULFATE (Amphastar Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (BE Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Camber Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Civica), NEOSTIGMINE METHYLSULFATE (Civica), NEOSTIGMINE METHYLSULFATE (General Injectables and Vaccines), NEOSTIGMINE METHYLSULFATE (Gland Pharma Limited), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Par Pharmaceutical), NEOSTIGMINE METHYLSULFATE (Xiromed LLC)
Formula
C12H19N2O2. CH3SO4
Exact mass
334.1199
Mol weight
334.3886
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Other
 DG01719  Parasympathomimetic agent
Remark
Same as: C08200
Therapeutic category: 1233
ATC code: N07AA01 S01EB06
Chemical structure group: DG00987
Product (DG00987): D00995<JP> D00998<JP/US>
Product (mixture): D04114<JP> D09186<JP>
Efficacy
Parasympathomimetic, Acetylcholinesterase inhibitor
Comment
Physostigmine derivative
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA01 Neostigmine
      D00998  Neostigmine methylsulfate (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB06 Neostigmine
      D00998  Neostigmine methylsulfate (JP17/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1233  Neostigmines
     D00998  Neostigmine methylsulfate (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  62 General eye drops
   D00998  Neostigmine methylsulfate (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Neostigmine
    D00998  Neostigmine methylsulfate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D00998  Neostigmine methylsulfate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00998  Neostigmine methylsulfate
  D00998  Neostigmine methylsulfate injection
Other DBs
CAS: 51-60-5
PubChem: 7848061
ChEBI: 7516
ChEMBL: CHEMBL211471
LigandBox: D00998
NIKKAJI: J262.808B
KCF data

ATOM        22
            1   C8y C    21.6932  -17.0217
            2   C8x C    22.9128  -16.3157
            3   C8x C    21.6932  -18.4279
            4   O7a O    20.4737  -16.3214
            5   C8y C    24.1207  -17.0217
            6   C8x C    22.9128  -19.1281
            7   C7a C    19.2600  -17.0274
            8   C8x C    24.1207  -18.4221
            9   N1d N    25.3402  -16.3157 #+
            10  N1c N    18.0405  -16.3274
            11  O6a O    19.2600  -18.4338
            12  C1a C    26.7988  -15.3937
            13  C1a C    24.6750  -15.2537
            14  C1a C    26.1630  -17.5234
            15  C1a C    16.8326  -17.0334
            16  C1a C    18.0405  -14.9210
            17  S4a S    32.7856  -17.4302
            18  O2a O    31.4201  -17.4243
            19  O1d O    32.7739  -18.7022
            20  O1d O    32.7272  -15.8138
            21  O1d O    34.1686  -17.4302 #-
            22  C1a C    30.6791  -16.3389
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 2
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16    6   8 1
            17   17  18 1
            18   17  19 2
            19   17  20 2
            20   17  21 1
            21   18  22 1

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