KEGG   DRUG: Acetylcholine chloride
Entry
D00999                      Drug                                   
Name
Acetylcholine chloride (JP18/USP/INN);
Miochol (TN)
Product
MIOCHOL E (Bausch & Lomb Incorporated)
Formula
C7H16NO2. Cl
Exact mass
181.0870
Mol weight
181.66
Structure
Simcomp
Class
Cardiovascular agent
 DG01532  Nicotinic cholinergic receptor agonist
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG02974  ACHE substrate
Remark
Same as: C08201
Therapeutic category: 1232 7222
ATC code: S01EB09
Chemical structure group: DG01133
Product (DG01133): D00999<JP/US>
Efficacy
Miotic, Vasodilator (peripheral), Cholinergic receptor agonist
Comment
Quaternary ammonium compound
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
CHRN [HSA:1134 1135 1136 1137 1138 8973 1139 55584 57053 1140 1141 1142 1143 1144 1145 1146] [KO:K04803 K04804 K04805 K04806 K04807 K04808 K04809 K04810 K04811 K04812 K04813 K04814 K04815 K04816 K04817 K04818]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: ACHE [HSA:43]
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB09 Acetylcholine
      D00999  Acetylcholine chloride (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1232  Acetylcholines
     D00999  Acetylcholine chloride (JP18/USP/INN)
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   722  Various function testing reagents
    7222  Diagnostic reagents for circulatory function
     D00999  Acetylcholine chloride (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01532  Nicotinic cholinergic receptor agonist
   DG01133  Acetylcholine
    D00999  Acetylcholine chloride
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG01133  Acetylcholine
    D00999  Acetylcholine chloride
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01133  Acetylcholine
    D00999  Acetylcholine chloride
 Metabolizing enzyme substrate
  DG02974  ACHE substrate
   DG01133  Acetylcholine
    D00999  Acetylcholine chloride
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00999  Acetylcholine chloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00999  Acetylcholine chloride (JP18/USP/INN) <JP/US>
 Ion channels
  Ligand-gated ion channels
   Acetylcholine (nicotinic)
    CHRN
     D00999  Acetylcholine chloride (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00999  Acetylcholine chloride for injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00999
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01532  Nicotinic cholinergic receptor agonist
   DG01133  Acetylcholine
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG01133  Acetylcholine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01133  Acetylcholine
 Metabolizing enzyme substrate
  DG02974  ACHE substrate
   DG01133  Acetylcholine
Other DBs
CAS: 60-31-1
PubChem: 7848062
ChEBI: 2417
LigandBox: D00999
NIKKAJI: J231.275A
KCF data

ATOM        11
            1   N1d N    17.4483  -17.4183 #+
            2   C1b C    18.5738  -18.0657
            3   C1a C    16.6728  -15.9663
            4   C1a C    15.9437  -17.4126
            5   C1a C    16.6728  -18.8646
            6   C1b C    19.7051  -17.4183
            7   O7a O    20.8363  -18.0657
            8   C7a C    21.9677  -17.4183
            9   C1a C    23.0874  -18.0657
            10  O6a O    21.9677  -16.1121
            11  X   Cl   26.5628  -17.6982 #-
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     8  10 2

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Ontology (7)   
   KEGG BRITE (7)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (4)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (42)   
   KEGG ORTHOLOGY (21)   
   KEGG GENES (21)   
All databases (56)   

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