KEGG   DRUG: Apraclonidine hydrochlorideHelp
Entry
D01008                      Drug                                   

Name
Apraclonidine hydrochloride (JAN/USP);
Iopidine (TN)
Product
  Generic
Formula
C9H10Cl2N4. HCl
Exact mass
280.0049
Mol weight
281.5694
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Remark
Therapeutic category: 1319
ATC code: S01EA03
Chemical structure group: DG01130
Product (DG01130): D01008<JP/US>
Efficacy
Antihypertensive (intraocular), alpha2-Adrenergic receptor agonist
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA03 Apraclonidine
      D01008  Apraclonidine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Alpha-adrenergic Agonists, Ophthalmic
    Apraclonidine
     D01008  Apraclonidine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01008  Apraclonidine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D01008  Apraclonidine hydrochloride (JAN/USP) <JP/US>
BRITE hierarchy
Other DBs
CAS: 73218-79-8
PubChem: 7848071
ChEBI: 2789
ChEMBL: CHEMBL1200379
DrugBank: DB00964
LigandBox: D01008
NIKKAJI: J327.542F
KCF data Show

ATOM        16
            1   X   Cl   21.4656  -17.6574
            2   C8x C    12.8100  -16.9400
            3   C8y C    12.8100  -18.3400
            4   C8x C    14.0000  -19.0400
            5   C8y C    15.2600  -18.3400
            6   C8y C    15.2600  -16.9400
            7   C8y C    14.0000  -16.2400
            8   X   Cl   16.4500  -19.0400
            9   N2x N    17.6400  -18.3400
            10  C2y C    17.6400  -16.9400
            11  N1b N    16.4500  -16.2400
            12  C1x C    18.9700  -18.7600
            13  C1x C    19.8100  -17.6400
            14  N1x N    18.9700  -16.5200
            15  X   Cl   14.0000  -14.8400
            16  N1a N    11.5947  -19.0351
BOND        16
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     9  10 2
            9    10  11 1
            10    6  11 1
            11    9  12 1
            12   12  13 1
            13   13  14 1
            14   10  14 1
            15    7  15 1
            16    3  16 1

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