KEGG   DRUG: Ibuprofen piconolHelp
Entry
D01122                      Drug                                   

Name
Ibuprofen piconol (JP17/USAN);
Staderm (TN)
Formula
C19H23NO2
Exact mass
297.1729
Mol weight
297.3914
Structure
Mol fileKCF fileDB search
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2649
ATC code: C01EB16 G02CC01 M01AE01 M02AA13 R02AX02
Chemical structure group: DG00245
Product (DG00245): D00126<JP/US> D01122<JP> D06606<JP/US>
Product (mixture): D11573<US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Propionic acid derivative
Active form of prodrug: Ibuprofen [DR:D00126]
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
map07048  Antimigraines
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB16 Ibuprofen
      D01122  Ibuprofen piconol (JP17/USAN) <JP>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC01 Ibuprofen
      D01122  Ibuprofen piconol (JP17/USAN) <JP>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE01 Ibuprofen
      D01122  Ibuprofen piconol (JP17/USAN) <JP>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA13 Ibuprofen
      D01122  Ibuprofen piconol (JP17/USAN) <JP>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX02 Ibuprofen
      D01122  Ibuprofen piconol (JP17/USAN) <JP>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ibuprofen
    D01122  Ibuprofen piconol (JP17/USAN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Ibuprofen
    D01122  Ibuprofen piconol (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D01122  Ibuprofen piconol (JP17/USAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D01122  Ibuprofen piconol (JP17/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ibuprofen piconol
    D01122  Ibuprofen piconol (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01122  Ibuprofen piconol (JP17/USAN) <JP>
    PTGS2 (COX2)
     D01122  Ibuprofen piconol (JP17/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01122  Ibuprofen piconol ointment
  D01122  Ibuprofen piconol cream
Rx-to-OTC switch list in Japan [br08314.html]
 D01122
Prodrugs [br08324.html]
 D01122
BRITE hierarchy
Other DBs
CAS: 112017-99-9
PubChem: 7848185
ChEBI: 31685
ChEMBL: CHEMBL2106254
DrugBank: DB01050
LigandBox: D01122
KCF data Show

ATOM        22
            1   C8x C    30.7421  -16.2559
            2   C8y C    30.7421  -17.6563
            3   N5x N    31.9578  -18.3565
            4   C8x C    33.1663  -17.6563
            5   C8x C    33.1663  -16.2559
            6   C8x C    31.9578  -15.5557
            7   C1b C    29.5296  -18.3570
            8   O7a O    28.3166  -17.6575
            9   C7a C    27.1042  -18.3583
            10  C1c C    25.8910  -17.6587
            11  O6a O    27.1048  -19.7587
            12  C8y C    24.6787  -18.3595
            13  C8x C    23.4712  -17.6571
            14  C8x C    22.2589  -18.3580
            15  C8y C    22.2595  -19.7584
            16  C8x C    23.4727  -20.4579
            17  C8x C    24.6850  -19.7570
            18  C1b C    21.0471  -20.4591
            19  C1c C    19.8339  -19.7596
            20  C1a C    18.6216  -20.4604
            21  C1a C    19.8332  -18.3592
            22  C1a C    25.8903  -16.2583
BOND        23
            1     9  11 2
            2     5   6 2
            3    10  12 1
            4     6   1 1
            5     2   7 1
            6     1   2 2
            7     7   8 1
            8    12  13 2
            9    13  14 1
            10   14  15 2
            11   15  16 1
            12   16  17 2
            13   17  12 1
            14    2   3 1
            15   15  18 1
            16    8   9 1
            17   18  19 1
            18    3   4 2
            19   19  20 1
            20    9  10 1
            21   19  21 1
            22    4   5 1
            23   10  22 1

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