KEGG   DRUG: Alprenolol hydrochlorideHelp
Entry
D01182                      Drug                                   

Name
Alprenolol hydrochloride (JP17/USAN);
Regletin (TN)
Formula
C15H23NO2. HCl
Exact mass
285.1496
Mol weight
285.8096
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 2123
ATC code: C07AA01
Chemical structure group: DG00303
Efficacy
Antiarrhythmic, beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA01 Alprenolol
      D01182  Alprenolol hydrochloride (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D01182  Alprenolol hydrochloride (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D01182  Alprenolol hydrochloride (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01182  Alprenolol hydrochloride
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D01182
BRITE hierarchy
Other DBs
CAS: 13707-88-5
PubChem: 7848245
ChEBI: 31191
ChEMBL: CHEMBL1256179
DrugBank: DB00866
LigandBox: D01182
NIKKAJI: J280.755F
KCF data Show

ATOM        19
            1   C1b C    12.2500   -5.1800
            2   C1c C    13.4400   -5.8800
            3   C1b C    14.6300   -5.1800
            4   N1b N    15.8200   -5.8800
            5   C1c C    17.0800   -5.1800
            6   C1a C    18.2700   -5.8800
            7   O2a O    10.9900   -5.8800
            8   O1a O    13.4400   -7.2800
            9   C1a C    17.0800   -3.7800
            10  C8y C    10.9900   -7.2800
            11  C8y C     9.7776   -7.9800
            12  C8x C     9.7776   -9.3800
            13  C8x C    10.9900  -10.0800
            14  C8x C    12.2024   -9.3800
            15  C8x C    12.2024   -7.9800
            16  C1b C     8.5821   -7.2896
            17  C2b C     7.3947   -7.9751
            18  C2a C     7.3947   -9.3751
            19  X   Cl   16.8000   -9.1700
BOND        18
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     2   8 1
            6     7   1 1
            7     5   9 1
            8     1   2 1
            9     7  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   10  15 1
            16   11  16 1
            17   16  17 1
            18   17  18 2

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