KEGG   DRUG: Pimilprost
Entry
D01188                      Drug                                   

Name
Pimilprost (JAN/INN)
Formula
C23H40O5
Exact mass
396.2876
Mol weight
396.5607
Structure
Class
Cardiovascular agent
 DG01810  Prostacycline derivative
Other
 DG01961  Prostaglandin derivative
  DG01810  Prostacycline derivative
 DG02573  Prostanoid derivative
  DG01961  Prostaglandin derivative
   DG01810  Prostacycline derivative
Efficacy
Anti-ulcerative (skin), Platelet aggregation inhibitor, Prostaglandin I2 receptor agonist
Comment
Prostacycline derivative
Target
PTGIR [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
Interaction
Structure map
map07228  Eicosanoid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    PTGIR
     D01188  Pimilprost (JAN/INN)
Other DBs
CAS: 139403-31-9
PubChem: 7848251
ChEBI: 32002
ChEMBL: CHEMBL2106962
LigandBox: D01188
NIKKAJI: J561.793F
KCF data

ATOM        28
            1   C1x C     7.8400  -22.3300
            2   C1y C     8.6100  -23.4500
            3   C1y C     9.9400  -22.9600
            4   C1y C     9.9400  -21.5600
            5   C1y C     8.6100  -21.1400
            6   C2b C    11.2000  -23.6600
            7   C2b C    12.3900  -22.9600
            8   C1c C    13.5800  -23.5900
            9   C1b C    14.7700  -22.8900
            10  C1c C    16.0300  -23.5900
            11  C1b C    17.2200  -22.8900
            12  C1b C    18.4100  -23.5900
            13  C1b C    19.6700  -22.8900
            14  C1a C    20.8600  -23.5900
            15  O1a O    13.5800  -24.9900
            16  C1a C    16.0300  -24.9900
            17  O1a O     8.1900  -24.7800
            18  C1x C    10.7800  -20.4400
            19  C1y C     9.9400  -19.3200
            20  C1x C     8.6100  -19.7400
            21  C1b C    10.3600  -17.9900
            22  C1b C    11.5500  -17.2900
            23  O2a O    12.7400  -17.9900
            24  C1b C    13.9300  -17.2900
            25  C7a C    15.1200  -17.9900
            26  O7a O    16.3100  -17.2900
            27  O6a O    15.1200  -19.3900
            28  C1a C    17.5000  -17.9900
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     3   6 1 #Up
            7     6   7 2
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    8  15 1 #Down
            16   10  16 1 #Down
            17    2  17 1 #Down
            18    4  18 1 #Down
            19   18  19 1
            20   19  20 1
            21    5  20 1 #Down
            22   19  21 1 #Up
            23   22  23 1
            24   22  21 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 2
            29   26  28 1

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