KEGG   DRUG: TrapidilHelp
Entry
D01220                      Drug                                   

Name
Trapidil (JP17/INN);
Rocornal (TN)
Formula
C10H15N5
Exact mass
205.1327
Mol weight
205.2596
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
  DG01516  Thromboxane A2 synthase inhibitor
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
   DG01516  Thromboxane A2 synthase inhibitor
 DG01516  Thromboxane A2 synthase inhibitor
Remark
Therapeutic category: 2171
ATC code: C01DX11
Product: D01220<JP>
Efficacy
Vasodilator, Phosphodiesterase inhibitor
Target
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04611  Platelet activation
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DX Other vasodilators used in cardiac diseases
     C01DX11 Trapidil
      D01220  Trapidil (JP17/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D01220  Trapidil (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    PDE
     D01220  Trapidil (JP17/INN) <JP>
  Isomerases (EC5)
   Thromboxane-A synthase
    TBXAS1 (CYP5A1)
     D01220  Trapidil (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01220  Trapidil
BRITE hierarchy
Other DBs
CAS: 15421-84-8
PubChem: 7848283
ChEBI: 32254
ChEMBL: CHEMBL132767
PDB-CCD: K1S[PDBj]
LigandBox: D01220
NIKKAJI: J3.445B
KCF data Show

ATOM        15
            1   C8y C    12.3900  -17.5700
            2   N4y N    12.3900  -16.1700
            3   C8y C    11.1776  -15.4700
            4   C8x C     9.9651  -16.1700
            5   C8y C     9.9651  -17.5700
            6   N5x N    11.1776  -18.2700
            7   N5x N    13.7215  -18.0026
            8   C8x C    14.5444  -16.8700
            9   N5x N    13.7215  -15.7374
            10  N1c N    11.1776  -14.0702
            11  C1b C    12.4068  -13.3603
            12  C1b C     9.9820  -13.3798
            13  C1a C     8.7948  -14.0652
            14  C1a C    13.6108  -14.0554
            15  C1a C     8.7340  -18.2810
BOND        16
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 2
            8     7   8 1
            9     8   9 2
            10    2   9 1
            11    3  10 1
            12   10  11 1
            13   10  12 1
            14   12  13 1
            15   11  14 1
            16    5  15 1

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