KEGG DRUG: Bromazepam

DRUG: Bromazepam

Entry

D01245                      Drug

Name

Bromazepam (JP18/USAN/INN);
Lectopam (TN)

Formula

C14H10BrN3O

Exact mass

315.0007

Mol weight

316.1527

Structure

Simcomp

Class

Neuropsychiatric agent
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives

Remark

Therapeutic category:

1124

ATC code:

N05BA08

Product:

D01245<JP>

Efficacy

Antianxiety, Minor tranquilizer, Sedative-hypnotic

Comment

Benzodiazepine derivative

Target

GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04727

GABAergic synapse

Interaction

Structure map

map07230

GABA-A receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA08 Bromazepam
      D01245  Bromazepam (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01245  Bromazepam (JP18/USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D01245  Bromazepam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D01245  Bromazepam
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01245  Bromazepam (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01245  Bromazepam
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
  D01245

Other DBs

CAS:

1812-30-2

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        19
            1   C8y C    22.4658  -15.1408
            2   N1x N    23.7321  -14.5533
            3   C5x C    24.9889  -15.1713
            4   C1x C    25.2855  -16.5295
            5   C8y C    22.1408  -16.5117
            6   N2x N    24.4084  -17.6240
            7   C2y C    23.0070  -17.6120
            8   C8y C    22.3836  -18.8818
            9   N5x N    21.0001  -18.8853
            10  C8x C    20.3041  -20.1001
            11  C8x C    21.0080  -21.3102
            12  C8x C    22.3927  -21.3057
            13  C8x C    23.0887  -20.0909
            14  C8x C    21.4475  -14.1800
            15  C8x C    20.1063  -14.5815
            16  C8y C    19.7813  -15.9524
            17  C8x C    20.7996  -16.9132
            18  X   Br   18.4645  -16.3469
            19  O5x O    26.0827  -14.3148
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    1  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19    5  17 2
            20   16  18 1
            21    3  19 2

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