| Entry |
|
|---|
| Name |
Atazanavir sulfate (JAN/USAN);
Reyataz (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C38H52N6O7. H2SO4
|
|---|
| Exact mass |
802.3571
|
|---|
| Mol weight |
802.934
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG01647 HIV protease inhibitor
Metabolizing enzyme inhibitor
DG01522 CYP3A4 inhibitor
DG02887 UGT inhibitor
|
|---|
| Remark |
| Therapeutic category: | 6250 |
| Product (DG00657): | D01276<JP/US> |
| Product (mixture): | D10753<US> |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Disease |
|
|---|
| Comment |
Treatment of acute and chronic HIV infection
|
|---|
| Target |
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
Enzyme inhibition: UGT1A1 [HSA: 54658]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE08 Atazanavir
D01276 Atazanavir sulfate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors (PI)
Atazanavir
D01276 Atazanavir sulfate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D01276 Atazanavir sulfate (JAN/USAN)
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01276
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01276
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01276
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01276
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01276
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 56
1 C1b C 27.2395 -17.2356
2 C1a C 15.6253 -19.5293
3 O7a O 16.7868 -20.2017
4 C7a C 17.9482 -19.5293
5 N1b N 19.1096 -20.2017
6 C1c C 20.2710 -19.5293
7 C5a C 21.4324 -20.2017
8 N1b N 22.5939 -19.5293
9 C1c C 23.7553 -20.2017
10 C1c C 24.9167 -19.5293
11 C1b C 26.0781 -20.2017
12 N1c N 27.2395 -19.5293
13 N1b N 28.4010 -20.2017
14 C5a C 29.5624 -19.5293
15 C1c C 30.7238 -20.2017
16 N1b N 31.8851 -19.5293
17 C7a C 33.0467 -20.2017
18 O7a O 34.2081 -19.5293
19 C1a C 35.3695 -20.2017
20 O6a O 17.9482 -18.1844
21 C1d C 20.2710 -17.0353
22 C1a C 20.3275 -15.6905
23 O5a O 21.4324 -21.5465
24 C1b C 23.7553 -21.5465
25 C8y C 24.9200 -22.2189
26 C8x C 24.9164 -23.5637
27 C8x C 26.0810 -24.2361
28 C8x C 27.2456 -23.5637
29 C8x C 27.2456 -22.2189
30 C8x C 26.0810 -21.5465
31 O1a O 24.9167 -18.1844
32 O5a O 29.5624 -18.1844
33 C1d C 30.7238 -22.4923
34 C1a C 30.7169 -23.8372
35 O6a O 33.0467 -21.5465
36 C1a C 21.6085 -17.0283
37 C1a C 18.8980 -17.0426
38 C8y C 28.4182 -16.5553
39 C8x C 29.5595 -17.2144
40 C8x C 30.7334 -16.5368
41 C8y C 30.7336 -15.1814
42 C8x C 29.5923 -14.5223
43 C8x C 28.4184 -15.1999
44 C8y C 31.9257 -14.4931
45 N5x N 33.0920 -15.1666
46 C8x C 34.2659 -14.4889
47 C8x C 34.2660 -13.1335
48 C8x C 33.0997 -12.4600
49 C8x C 31.9258 -13.1376
50 C1a C 32.0455 -22.4959
51 C1a C 29.3347 -22.4886
52 S4a S 16.6884 -22.8888
53 O1d O 15.3382 -22.8888
54 O1d O 18.0386 -22.8888
55 O1d O 16.6829 -21.5330
56 O1d O 16.6829 -24.2390
BOND 57
1 21 22 1
2 8 9 1
3 7 23 2
4 9 24 1 #Down
5 9 10 1
6 24 25 1
7 10 11 1
8 11 12 1
9 2 3 1
10 25 26 2
11 26 27 1
12 27 28 2
13 28 29 1
14 29 30 2
15 30 25 1
16 12 13 1
17 10 31 1 #Up
18 12 1 1
19 14 32 2
20 13 14 1
21 15 33 1 #Up
22 3 4 1
23 14 15 1
24 33 34 1
25 15 16 1
26 17 35 2
27 4 5 1
28 16 17 1
29 17 18 1
30 5 6 1
31 18 19 1
32 4 20 2
33 6 7 1
34 6 21 1 #Up
35 7 8 1
36 21 36 1
37 21 37 1
38 1 38 1
39 38 39 2
40 39 40 1
41 40 41 2
42 41 42 1
43 42 43 2
44 38 43 1
45 41 44 1
46 44 45 2
47 45 46 1
48 46 47 2
49 47 48 1
50 48 49 2
51 44 49 1
52 33 50 1
53 33 51 1
54 52 53 1
55 52 54 1
56 52 55 2
57 52 56 2
|
|---|
