KEGG   DRUG: DroxidopaHelp
Entry
D01277                      Drug                                   

Name
Droxidopa (JP17/INN);
Dops (TN);
Northera (TN)
Product
Formula
C9H11NO5
Exact mass
213.0637
Mol weight
213.1873
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01967  Antiparkinson agent
Remark
Therapeutic category: 1169
ATC code: C01CA27
Product: D01277<JP/US>
Efficacy
Antiparkinsonian, Replenisher (noradrenalin)
  Disease
Parkinson disease [DS:H00057]
Multiple system atrophy [DS:H01614]
Dopamine beta-hydroxylase deficiency [DS:H01005]
Comment
precursor of Norepinephrine [DR:D00076]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Drug interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA27 Droxidopa
      D01277  Droxidopa (JP17/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Droxidopa
    D01277  Droxidopa (JP17/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D01277  Droxidopa (JP17/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01277  Droxidopa (JP17/INN) <JP/US>
    ADRA2
     D01277  Droxidopa (JP17/INN) <JP/US>
    ADRB
     D01277  Droxidopa (JP17/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01277  Droxidopa
  D01277  Droxidopa capsules
  D01277  Droxidopa fine granules
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01277
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01277
BRITE hierarchy
Other DBs
CAS: 23651-95-8
PubChem: 7848340
ChEBI: 31524
ChEMBL: CHEMBL2103827
LigandBox: D01277
NIKKAJI: J22.085J
KCF data Show

ATOM        15
            1   C8y C     5.1800   -5.1100
            2   C8y C     5.1800   -6.5100
            3   C8x C     6.4400   -7.2100
            4   C8x C     7.6300   -6.5100
            5   C8y C     7.6300   -5.1100
            6   C8x C     6.4400   -4.4100
            7   O1a O     3.9900   -7.2100
            8   C1c C     8.8200   -4.4100
            9   C1c C    10.0100   -5.1100
            10  C6a C    11.2700   -4.4100
            11  O6a O    12.4600   -5.1100
            12  O6a O    11.2700   -3.0100
            13  O1a O     8.8200   -3.0100
            14  N1a N    10.0100   -6.5100
            15  O1a O     3.9734   -4.4000
BOND        15
            1     1   2 2
            2     2   3 1
            3     5   8 1
            4     3   4 2
            5     8   9 1
            6     4   5 1
            7     9  10 1
            8     5   6 2
            9    10  11 1
            10    6   1 1
            11   10  12 2
            12    8  13 1 #Up
            13    2   7 1
            14    9  14 1 #Up
            15    1  15 1

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