| Entry |
|
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| Name |
Lofepramine hydrochloride (JAN/USAN);
Amplit (TN) |
|---|
| Formula |
C26H27ClN2O. HCl
|
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| Exact mass |
454.1579
|
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| Mol weight |
455.4193
|
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
|
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| Remark |
| Therapeutic category: | 1174 |
| Product (DG00932): | D01285<JP> |
|
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
|---|
| Target |
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| Pathway |
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| Interaction |
|
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA07 Lofepramine
D01285 Lofepramine hydrochloride (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1174 Imipramines
D01285 Lofepramine hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00932 Lofepramine
D01285 Lofepramine hydrochloride
DG01728 Tricyclic antidepressant
DG00932 Lofepramine
D01285 Lofepramine hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D01285 Lofepramine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D01285 Lofepramine hydrochloride (JAN/USAN) <JP>
SLC6A4 (HTT)
D01285 Lofepramine hydrochloride (JAN/USAN) <JP>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00932 Lofepramine
DG01728 Tricyclic antidepressant
DG00932 Lofepramine
|
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| Other DBs |
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| KCF data |
ATOM 31
1 C1x C 27.9300 -20.5800
2 C8y C 27.0900 -19.4600
3 C8y C 27.4400 -18.1300
4 N1y N 28.7000 -17.5700
5 C1x C 29.3300 -20.5800
6 C8y C 29.9600 -18.2000
7 C8y C 30.2400 -19.5300
8 C8x C 26.3900 -17.1500
9 C8x C 25.0600 -17.5700
10 C8x C 24.7100 -18.9000
11 C8x C 25.7600 -19.8800
12 C8x C 31.5700 -19.9500
13 C8x C 32.6200 -19.0400
14 C8x C 32.3400 -17.6400
15 C8x C 31.0100 -17.2200
16 C1b C 28.7000 -16.1700
17 C1b C 29.9124 -15.4700
18 C1b C 31.1079 -16.1604
19 N1c N 32.2953 -15.4749
20 C1b C 33.4865 -16.1629
21 C5a C 34.6760 -15.4762
22 C8y C 35.8661 -16.1635
23 O5a O 34.6762 -14.0702
24 C1a C 32.2955 -14.0702
25 C8x C 35.8661 -17.5698
26 C8x C 37.0785 -18.2698
27 C8y C 38.2909 -17.5699
28 C8x C 38.2910 -16.1637
29 C8x C 37.0786 -15.4636
30 X Cl 39.5027 -18.2696
31 X Cl 36.4000 -20.1600
BOND 33
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 21 23 2
26 19 24 1
27 22 25 2
28 25 26 1
29 26 27 2
30 27 28 1
31 28 29 2
32 22 29 1
33 27 30 1
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