| Entry |
|
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| Name |
Flunarizine hydrochloride (JAN/USAN) |
|---|
| Formula |
C26H26F2N2. 2HCl
|
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| Exact mass |
476.1598
|
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| Mol weight |
477.4167
|
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| Structure |
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01573 Calcium channel T type blocker
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
|
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| Efficacy |
Antivertigo, Vasodilator, Calcium antagonist |
|---|
| Target |
|
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| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07C ANTIVERTIGO PREPARATIONS
N07CA Antivertigo preparations
N07CA03 Flunarizine
D01303 Flunarizine hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01573 Calcium channel T type blocker
DG01006 Flunarizine
D01303 Flunarizine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01006 Flunarizine
D01303 Flunarizine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-T
D01303 Flunarizine hydrochloride (JAN/USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01303
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01573 Calcium channel T type blocker
DG01006 Flunarizine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01006 Flunarizine
|
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| Other DBs |
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| KCF data |
ATOM 32
1 C1c C 32.9047 -20.4996
2 C8y C 31.6903 -21.1975
3 C8y C 34.1164 -21.2023
4 C8x C 30.4848 -20.4979
5 C8x C 29.2704 -21.1960
6 C8y C 29.2677 -22.5966
7 C8x C 30.4794 -23.2991
8 C8x C 31.6936 -22.6012
9 C8x C 34.1060 -22.6017
10 C8x C 35.3177 -23.3044
11 C8y C 36.5320 -22.6066
12 C8x C 36.5349 -21.2060
13 C8x C 35.3231 -20.5033
14 X F 28.0533 -23.2944
15 X F 37.7437 -23.3093
16 N1y N 32.9074 -19.0988
17 C1x C 34.1218 -18.4009
18 C1x C 34.1245 -17.0003
19 N1y N 32.9130 -16.2976
20 C1x C 31.6987 -16.9954
21 C1x C 31.6959 -18.3960
22 C1b C 32.9158 -14.8970
23 C2b C 34.1301 -14.1989
24 C2b C 35.3684 -14.9170
25 C8y C 36.5712 -14.2255
26 C8x C 37.7523 -14.9103
27 C8x C 38.9660 -14.2126
28 C8x C 38.9686 -12.8126
29 C8x C 37.7876 -12.1278
30 C8x C 36.5739 -12.8255
31 X Cl 38.3236 -17.8908
32 X Cl 38.3236 -17.8908
BOND 33
1 16 17 1
2 17 18 1
3 18 19 1
4 19 20 1
5 20 21 1
6 21 16 1
7 1 2 1
8 19 22 1
9 1 3 1
10 3 9 2
11 9 10 1
12 10 11 2
13 11 12 1
14 12 13 2
15 13 3 1
16 2 4 2
17 6 14 1
18 22 23 1
19 4 5 1
20 11 15 1
21 5 6 2
22 1 16 1
23 6 7 1
24 7 8 2
25 8 2 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 28 29 1
32 29 30 2
33 25 30 1
BRACKET 1 36.7500 -18.6200 36.7500 -17.2200
1 39.1300 -17.2200 39.1300 -18.6200
1 2
ORIGINAL 1 31
REPEAT 1 32
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