KEGG   DRUG: DoxifluridineHelp
Entry
D01309                      Drug                                   

Name
Doxifluridine (JP17/INN);
Furtulon (TN)
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01935  Fluoropyrimidine antineoplastic
 DG01935  Fluoropyrimidine antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Remark
Same as: C12739
Therapeutic category: 4223
Product: D01309<JP>
Efficacy
Antineoplastic, Antimetabolite
Comment
Active form of prodrug: Fluorouracil [DR:D00584]
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Interaction
Drug interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4223  Fluorouracils
     D01309  Doxifluridine (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D01309  Doxifluridine (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01309  Doxifluridine
  D01309  Doxifluridine capsules
Antineoplastics [br08340.html]
 D01309
Prodrugs [br08324.html]
 D01309
BRITE hierarchy
Other DBs
CAS: 3094-09-5
PubChem: 7848372
ChEBI: 31521
ChEMBL: CHEMBL1130
LigandBox: D01309
NIKKAJI: J7.679A
KCF data Show

ATOM        17
            1   C1y C    22.8703  -17.4990
            2   N4y N    24.5207  -16.9314
            3   O2x O    21.7034  -16.6238
            4   C1y C    22.4328  -18.8118
            5   C8y C    25.7785  -17.6293
            6   C8x C    24.4865  -15.5558
            7   C1y C    20.6094  -17.4261
            8   C1y C    21.0470  -18.8118
            9   O1a O    23.2350  -19.9058
            10  N4x N    26.9723  -16.9258
            11  O5x O    25.7354  -18.9679
            12  C8y C    25.7504  -14.8522
            13  O1a O    20.2448  -19.9058
            14  C8y C    26.9711  -15.4873
            15  O5x O    28.1650  -14.7838
            16  C1a C    19.2967  -17.0614
            17  X   F    25.7492  -13.4138
BOND        18
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Down
            8     5  10 1
            9     5  11 2
            10    6  12 2
            11    8  13 1 #Down
            12   10  14 1
            13   14  15 2
            14    7   8 1
            15   12  14 1
            16    7  16 1 #Up
            17    1   2 1 #Up
            18   12  17 1

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