KEGG   DRUG: ClotiazepamHelp
Entry
D01328                      Drug                                   

Name
Clotiazepam (JP17/INN);
Rize (TN)
Formula
C16H15ClN2OS
Exact mass
318.0594
Mol weight
318.8211
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Remark
Therapeutic category: 1179
ATC code: N05BA21
Product: D01328<JP>
Efficacy
Antianxiety, Sedative-hypnotic
Comment
Benzodiazepine derivative (thienodiazepine)
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA21 Clotiazepam
      D01328  Clotiazepam (JP17/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01328  Clotiazepam (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01328  Clotiazepam (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01328  Clotiazepam
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01328
BRITE hierarchy
Other DBs
CAS: 33671-46-4
PubChem: 7848391
ChEBI: 31425
ChEMBL: CHEMBL1697737
LigandBox: D01328
NIKKAJI: J9.292D
KCF data Show

ATOM        21
            1   C2y C    19.5296  -16.5337
            2   C8y C    18.6872  -15.4238
            3   C8y C    19.0225  -14.0666
            4   N1y N    20.2839  -13.4883
            5   N2x N    20.9358  -16.5589
            6   C5x C    21.5379  -14.1108
            7   C1x C    21.8245  -15.4799
            8   O5x O    22.5823  -13.1761
            9   C8y C    18.8949  -17.7838
            10  C8x C    17.4929  -17.7838
            11  S2x S    17.8354  -13.3283
            12  C8y C    16.7663  -14.2292
            13  C8x C    17.2928  -15.3842
            14  C8x C    16.7927  -18.9967
            15  C8x C    17.4929  -20.2094
            16  C8x C    18.8949  -20.2094
            17  C8y C    19.5951  -18.9967
            18  X   Cl   21.0064  -18.9968
            19  C1b C    15.3659  -14.2292
            20  C1a C    14.6516  -12.9913
            21  C1a C    20.3056  -12.1130
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     1   9 1
            10    9  10 1
            11    3  11 1
            12   11  12 1
            13   12  13 2
            14    2  13 1
            15   10  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19    9  17 2
            20   17  18 1
            21   12  19 1
            22   19  20 1
            23    4  21 1

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