KEGG   DRUG: Formoterol fumarateHelp
Entry
D01373                      Drug                                   

Name
Formoterol fumarate (USAN);
Foradil (TN)
Product
Formula
(C19H24N2O4)2. C4H4O4
Exact mass
804.3582
Mol weight
804.8819
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
Remark
ATC code: R03AC13
Chemical structure group: DG01052
Product (DG01052): D01373<US> D05277<JP/US>
Product (mixture): D10295<US> D11036<US>
Efficacy
Bronchodilator, beta2-Adrenergic receptor agonist
  Disease
Asthma [DS:H00079]
Chronic obstructive pulmonary disease [DS:H01714]
Comment
Phenethylamine derivative
Target
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AC Selective beta-2-adrenoreceptor agonists
     R03AC13 Formoterol
      D01373  Formoterol fumarate (USAN) <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Formoterol
    D01373  Formoterol fumarate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB2
     D01373  Formoterol fumarate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01373
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01373
BRITE hierarchy
Other DBs
CAS: 43229-80-7
PubChem: 7848436
ChEBI: 31633
DrugBank: DB00983
LigandBox: D01373
NIKKAJI: J364.822B
KCF data Show

ATOM        58
            1   C6a C    42.5268  -20.4767
            2   C2b C    43.7345  -21.1769
            3   O6a O    41.3191  -21.1769
            4   O6a O    42.5268  -19.0825
            5   C2b C    44.9479  -20.4767
            6   C6a C    46.1556  -21.1769
            7   O6a O    47.3633  -20.4767
            8   O6a O    46.1556  -22.5713
            9   C8y C    24.5700  -21.2100
            10  C8x C    23.3800  -21.9100
            11  C8x C    24.5700  -19.8100
            12  C1c C    25.7600  -21.9100
            13  C8y C    22.1200  -21.2100
            14  C8x C    23.3800  -19.1100
            15  C1b C    27.0200  -21.2100
            16  O1a O    25.7600  -23.3100
            17  C8y C    22.1200  -19.8100
            18  N1b N    20.9300  -21.9100
            19  N1b N    28.2100  -21.9100
            20  O1a O    20.9300  -19.1100
            21  C4a C    19.7400  -21.2100
            22  C1c C    29.4000  -21.2100
            23  O4a O    18.4800  -21.9100
            24  C1b C    30.5900  -21.9100
            25  C1a C    29.4000  -19.8100
            26  C8y C    31.8500  -21.2100
            27  C8x C    31.8500  -19.8100
            28  C8x C    33.0400  -21.9100
            29  C8x C    33.0400  -19.1100
            30  C8x C    34.2300  -21.2100
            31  C8y C    34.2300  -19.8100
            32  O2a O    35.4900  -19.0400
            33  C1a C    36.6800  -19.7400
            34  C8y C    24.5700  -21.2100
            35  C8x C    23.3800  -21.9100
            36  C8y C    22.1200  -21.2100
            37  C8y C    22.1200  -19.8100
            38  O1a O    20.9300  -19.1100
            39  C8x C    23.3800  -19.1100
            40  C8x C    24.5700  -19.8100
            41  N1b N    20.9300  -21.9100
            42  C4a C    19.7400  -21.2100
            43  O4a O    18.4800  -21.9100
            44  C1c C    25.7600  -21.9100
            45  C1b C    27.0200  -21.2100
            46  N1b N    28.2100  -21.9100
            47  C1c C    29.4000  -21.2100
            48  C1b C    30.5900  -21.9100
            49  C8y C    31.8500  -21.2100
            50  C8x C    31.8500  -19.8100
            51  C8x C    33.0400  -19.1100
            52  C8y C    34.2300  -19.8100
            53  O2a O    35.4900  -19.0400
            54  C1a C    36.6800  -19.7400
            55  C8x C    34.2300  -21.2100
            56  C8x C    33.0400  -21.9100
            57  C1a C    29.4000  -19.8100
            58  O1a O    25.7600  -23.3100
BOND        59
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     9  10 2
            9     9  11 1
            10    9  12 1
            11   10  13 1
            12   11  14 2
            13   12  15 1
            14   12  16 1
            15   13  17 2
            16   13  18 1
            17   15  19 1
            18   17  20 1
            19   18  21 1
            20   19  22 1
            21   21  23 2
            22   22  24 1
            23   22  25 1
            24   24  26 1
            25   26  27 2
            26   26  28 1
            27   27  29 1
            28   28  30 2
            29   29  31 2
            30   31  32 1
            31   32  33 1
            32   14  17 1
            33   30  31 1
            34   34  35 2
            35   34  40 1
            36   34  44 1
            37   35  36 1
            38   40  39 2
            39   44  45 1
            40   44  58 1
            41   36  37 2
            42   36  41 1
            43   45  46 1
            44   37  38 1
            45   41  42 1
            46   46  47 1
            47   42  43 2
            48   47  48 1
            49   47  57 1
            50   48  49 1
            51   49  50 2
            52   49  56 1
            53   50  51 1
            54   56  55 2
            55   51  52 2
            56   52  53 1
            57   53  54 1
            58   39  37 1
            59   55  52 1
BRACKET     1    17.2900  -24.0100   17.2900  -17.6400
            1    38.8500  -17.6400   38.8500  -24.0100
            1  2
 ORIGINAL  1    9  10  13  17  20  14  11  18  21  23  12  15  19  22  24  26
            1   27  29  31  32  33  30  28  25  16
 REPEAT    1   34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49
            1   50  51  52  53  54  55  56  57  58

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