KEGG   DRUG: Flurazepam hydrochlorideHelp
Entry
D01408                      Drug                                   

Name
Flurazepam hydrochloride (JP17);
Flurazepam monohydrochloride;
Dalmate (TN)
Formula
C21H23ClFN3O. HCl
Exact mass
423.128
Mol weight
424.3392
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG02036  Antiepileptics, benzodiazepine derivatives
Remark
Therapeutic category: 1124
ATC code: N05CD01
Chemical structure group: DG00919
Product (DG00919): D00695<US> D01408<JP>
Efficacy
Sedative-hypnotic
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD01 Flurazepam
      D01408  Flurazepam hydrochloride (JP17) <JP>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Flurazepam
    D01408  Flurazepam hydrochloride (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01408  Flurazepam hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01408  Flurazepam hydrochloride (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01408  Flurazepam hydrochloride
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01408
BRITE hierarchy
Other DBs
CAS: 36105-20-1
PubChem: 7848471
ChEBI: 31626
DrugBank: DB00690
LigandBox: D01408
NIKKAJI: J321.678K
KCF data Show

ATOM        28
            1   X   Cl   36.6766  -12.5550
            2   C2y C    31.7800  -13.0200
            3   C8y C    30.9400  -11.9000
            4   C8y C    31.2900  -10.5000
            5   N1y N    32.5500   -9.9400
            6   N2x N    33.2500  -13.0200
            7   C5x C    33.8100  -10.5700
            8   C1x C    34.0900  -11.9700
            9   C8x C    30.3100   -9.5200
            10  C8x C    28.9800   -9.9400
            11  C8y C    28.6300  -11.2700
            12  C8x C    29.6100  -12.2500
            13  O5x O    34.8600   -9.6600
            14  X   Cl   27.2300  -11.6900
            15  C8y C    31.1500  -14.2800
            16  C8x C    29.7500  -14.2800
            17  C8x C    29.0500  -15.4700
            18  C8x C    29.7500  -16.6600
            19  C8x C    31.1500  -16.6600
            20  C8y C    31.8500  -15.4700
            21  X   F    33.3200  -15.4700
            22  C1b C    32.5500   -8.5400
            23  C1b C    33.7400   -7.9100
            24  N1c N    33.7400   -6.4400
            25  C1b C    35.0000   -5.7400
            26  C1b C    32.5500   -5.7400
            27  C1a C    31.3600   -6.4400
            28  C1a C    36.1900   -6.4400
BOND        29
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    7  13 2
            14   11  14 1
            15    2  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   15  20 2
            22   20  21 1
            23    5  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1
            28   26  27 1
            29   25  28 1

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