| Entry |
|
|---|
| Name |
Cifenline succinate (USAN);
Cibenzoline succinate (JP18);
Cibenol (TN);
Cipralan (TN) |
|---|
| Formula |
C18H18N2. C4H6O4
|
|---|
| Exact mass |
380.1736
|
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| Mol weight |
380.437
|
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| Structure |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2129 |
| Product (DG00209): | D01455<JP> |
|
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| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BG Other antiarrhythmics, class I and III
C01BG07 Cibenzoline
D01455 Cifenline succinate (USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D01455 Cifenline succinate (USAN); Cibenzoline succinate (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00209 Cibenzoline
D01455 Cifenline succinate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00209 Cibenzoline
D01455 Cifenline succinate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00209 Cibenzoline
D01455 Cifenline succinate
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D01455 Cifenline succinate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D01455 Cifenline succinate (USAN) <JP>
SCN2A
D01455 Cifenline succinate (USAN) <JP>
SCN3A
D01455 Cifenline succinate (USAN) <JP>
SCN4A
D01455 Cifenline succinate (USAN) <JP>
SCN5A
D01455 Cifenline succinate (USAN) <JP>
SCN8A
D01455 Cifenline succinate (USAN) <JP>
SCN9A
D01455 Cifenline succinate (USAN) <JP>
SCN10A
D01455 Cifenline succinate (USAN) <JP>
SCN11A
D01455 Cifenline succinate (USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01455 Cibenzoline succinate
D01455 Cibenzoline succinate tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01455
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00209 Cibenzoline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00209 Cibenzoline
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00209 Cibenzoline
|
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| Other DBs |
|
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| KCF data |
ATOM 28
1 O6a O 28.6206 -16.4110
2 C6a C 29.8130 -17.1124
3 C1b C 31.0755 -16.4110
4 C1b C 32.2680 -17.1124
5 C6a C 33.4604 -16.4110
6 O6a O 34.7230 -17.1124
7 O6a O 29.8130 -18.5153
8 O6a O 33.4604 -15.0081
9 C8x C 19.5021 -17.8163
10 C8x C 19.5021 -19.2191
11 C8x C 20.6946 -19.9206
12 C8x C 21.9571 -19.2191
13 C8y C 21.9571 -17.8163
14 C8x C 20.6946 -17.1148
15 C1z C 23.1496 -17.1120
16 C1x C 22.4481 -15.9196
17 C1y C 23.8510 -15.9196
18 C2y C 25.0692 -15.2199
19 N2x N 26.3859 -15.6250
20 C1x C 27.1782 -14.4978
21 C1x C 26.3510 -13.3960
22 N1x N 25.0475 -13.8423
23 C8x C 24.3420 -19.2191
24 C8y C 24.3420 -17.8163
25 C8x C 25.6046 -19.9206
26 C8x C 26.7970 -19.2191
27 C8x C 26.7970 -17.8163
28 C8x C 25.6046 -17.1148
BOND 30
1 2 7 2
2 5 8 2
3 3 4 1
4 1 2 1
5 4 5 1
6 5 6 1
7 2 3 1
8 9 10 2
9 10 11 1
10 11 12 2
11 12 13 1
12 13 14 2
13 9 14 1
14 16 17 1
15 17 15 1
16 15 16 1
17 17 18 1
18 18 19 2
19 19 20 1
20 20 21 1
21 21 22 1
22 18 22 1
23 13 15 1
24 23 24 1
25 23 25 2
26 25 26 1
27 26 27 2
28 27 28 1
29 24 28 2
30 15 24 1
|
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