KEGG   DRUG: Sarpogrelate hydrochloride
Entry
D01624                      Drug                                   

Name
Sarpogrelate hydrochloride (JP17);
Anplag (TN)
Formula
C24H31NO6. HCl
Exact mass
465.1918
Mol weight
465.967
Structure
Simcomp
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02919  CYP2B6 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 3399
Chemical structure group: DG01333
Product (DG01333): D01624<JP>
Efficacy
Anticoagulant, Platelet aggregation inhibitor, Serotonin 5-HT2 receptor antagonist
Target
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07049  Antithrombosis agents
map07211  Serotonin receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D01624  Sarpogrelate hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR2A
     D01624  Sarpogrelate hydrochloride (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01624  Sarpogrelate hydrochloride
  D01624  Sarpogrelate hydrochloride tablets
  D01624  Sarpogrelate hydrochloride fine granules
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01624
Other DBs
CAS: 135159-51-2
PubChem: 7848687
ChEBI: 32122
ChEMBL: CHEMBL541829
LigandBox: D01624
NIKKAJI: J550.747B
KCF data

ATOM        32
            1   C8y C    20.8521  -17.4758
            2   O2a O    22.0660  -16.7720
            3   C8x C    19.6381  -16.7780
            4   C8y C    20.8521  -18.8773
            5   C1b C    23.2740  -17.4758
            6   C8x C    18.4301  -17.4758
            7   C8x C    19.6441  -19.5753
            8   C1c C    24.4879  -16.7720
            9   C8x C    18.4301  -18.8773
            10  O7a O    25.7019  -17.4758
            11  C1b C    24.4879  -15.3705
            12  C7a C    26.9100  -16.7720
            13  C1b C    28.1240  -17.4758
            14  C1b C    29.3380  -16.7720
            15  C6a C    30.5460  -17.4758
            16  O6a O    31.7599  -16.7720
            17  O6a O    26.9087  -15.3689
            18  O6a O    30.5446  -18.8789
            19  C1b C    22.0614  -19.5687
            20  C1b C    23.2732  -18.8671
            21  C8y C    24.4848  -19.5615
            22  C8x C    24.4893  -20.9581
            23  C8x C    25.7010  -21.6527
            24  C8x C    26.9083  -20.9505
            25  C8y C    26.9039  -19.5539
            26  C8x C    25.6922  -18.8595
            27  O2a O    28.1167  -18.8484
            28  C1a C    29.3341  -19.5460
            29  N1c N    23.2730  -14.6689
            30  C1a C    23.2730  -13.2659
            31  C1a C    22.0579  -15.3705
            32  X   Cl   33.1159  -19.4624
BOND        32
            1    15  16 1
            2     7   9 1
            3    12  17 2
            4    15  18 2
            5     1   2 1
            6     4  19 1
            7     1   3 2
            8    19  20 1
            9     1   4 1
            10   20  21 1
            11    2   5 1
            12    3   6 1
            13    4   7 2
            14    5   8 1
            15    6   9 2
            16   21  22 2
            17   22  23 1
            18   23  24 2
            19   24  25 1
            20   25  26 2
            21   26  21 1
            22    8  10 1
            23   25  27 1
            24    8  11 1
            25   27  28 1
            26   10  12 1
            27   11  29 1
            28   12  13 1
            29   29  30 1
            30   13  14 1
            31   29  31 1
            32   14  15 1

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