KEGG   DRUG: Milrinone lactateHelp
Entry
D02085                      Drug                                   

Name
Milrinone lactate;
Primacor (TN)
Product
  Generic
Formula
C12H9N3O. (C3H6O3)x
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01757  Amrinone type cardiotonic
 DG01507  Phosphodiesterase III inhibitor
  DG01757  Amrinone type cardiotonic
Remark
ATC code: C01CE02
Chemical structure group: DG00229
Product (DG00229): D00417<JP> D02085<US>
Efficacy
Cardiotonic, Phosphodiesterase 3 inhibitor
  Disease
Acute decompensated heart failure [DS:H01631]
Comment
Amrinone derivative
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296]
  Pathway
hsa00230  Purine metabolism
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04371  Apelin signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CE Phosphodiesterase inhibitors
     C01CE02 Milrinone
      D02085  Milrinone lactate <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE3
     D02085  Milrinone lactate <US>
BRITE hierarchy
Other DBs
CAS: 100286-97-3
PubChem: 7849146
ChEBI: 34850
ChEMBL: CHEMBL1200977
DrugBank: DB00235
LigandBox: D02085
NIKKAJI: J2.203.864H
KCF data Show

ATOM        22
            1   C8y C    27.4735  -17.2583
            2   C8y C    28.6858  -16.5588
            3   C8x C    26.2669  -16.5588
            4   C8y C    27.4735  -18.6570
            5   C8x C    29.8983  -17.2583
            6   C8x C    28.6858  -15.1599
            7   C8y C    25.0487  -17.2583
            8   N4x N    26.2669  -19.3624
            9   C1a C    28.6801  -19.3565
            10  C8x C    31.1165  -16.5705
            11  C8x C    29.9040  -14.4604
            12  C8y C    25.0487  -18.6570
            13  C3b C    23.8364  -16.5588
            14  N5x N    31.1165  -15.1599
            15  O5x O    23.8364  -19.3624
            16  N3a N    22.6239  -15.8594
            17  C1c C    36.8899  -17.6785
            18  C6a C    38.0965  -16.9908
            19  C1a C    36.8840  -19.0833
            20  O1a O    35.6776  -16.9849
            21  O6a O    38.0905  -15.5919
            22  O6a O    39.3088  -17.6901
BOND        22
            1     2   6 1
            2     3   7 2
            3     4   8 1
            4     4   9 1
            5     5  10 1
            6     6  11 2
            7     7  12 1
            8     7  13 1
            9    10  14 2
            10   12  15 2
            11   13  16 3
            12    8  12 1
            13   11  14 1
            14    1   2 1
            15    1   3 1
            16    1   4 2
            17    2   5 2
            18   17  18 1
            19   17  19 1
            20   17  20 1
            21   18  21 2
            22   18  22 1
BRACKET     1    34.0200  -19.8800   34.0200  -14.7000
            1    40.8100  -14.7000   40.8100  -19.8800
            1  x
 ORIGINAL  1   17  18  19  20  21  22
 REPEAT    1

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