KEGG   DRUG: Tocainide hydrochlorideHelp
Entry
D02088                      Drug                                   

Name
Tocainide hydrochloride (USP);
Tonocard (TN)
Formula
C11H16N2O. HCl
Exact mass
228.1029
Mol weight
228.7185
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Remark
ATC code: C01BB03
Chemical structure group: DG00198
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB03 Tocainide
      D02088  Tocainide hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02088  Tocainide hydrochloride (USP)
    SCN2A
     D02088  Tocainide hydrochloride (USP)
    SCN3A
     D02088  Tocainide hydrochloride (USP)
    SCN4A
     D02088  Tocainide hydrochloride (USP)
    SCN5A
     D02088  Tocainide hydrochloride (USP)
    SCN8A
     D02088  Tocainide hydrochloride (USP)
    SCN9A
     D02088  Tocainide hydrochloride (USP)
    SCN10A
     D02088  Tocainide hydrochloride (USP)
    SCN11A
     D02088  Tocainide hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 35891-93-1
PubChem: 7849149
ChEMBL: CHEMBL1200773
DrugBank: DB01056
LigandBox: D02088
NIKKAJI: J540.743E
KCF data Show

ATOM        15
            1   C8y C    24.4404  -17.9552
            2   N1b N    23.2290  -17.2622
            3   C8y C    24.4345  -19.3645
            4   C8y C    25.6517  -17.2680
            5   C5a C    22.0178  -17.9494
            6   C8x C    25.6517  -20.0693
            7   C1a C    23.2174  -20.0634
            8   C8x C    26.8572  -17.9611
            9   C1a C    25.5876  -15.8588
            10  C1c C    20.8063  -17.2506
            11  O5a O    22.0818  -19.3471
            12  C8x C    26.8631  -19.3645
            13  C1a C    19.5951  -17.9435
            14  N1a N    20.8063  -15.8471
            15  X   Cl   30.2865  -18.0600
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 1
            14    8  12 2

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