KEGG   DRUG: Ipratropium bromideHelp
Entry
D02212                      Drug                                   

Name
Ipratropium bromide (USAN);
Ipratropium bromide hydrate (JP17);
Atrovent (TN)
Product
  Generic
IPRATROPIUM BROMIDE (A-S Medication Solutions), IPRATROPIUM BROMIDE (Actavis Pharma), IPRATROPIUM BROMIDE (Aidarex Pharmaceuticals LLC), IPRATROPIUM BROMIDE (American Health Packaging), IPRATROPIUM BROMIDE (Aurobindo Pharma Limited), IPRATROPIUM BROMIDE (Bausch & Lomb Incorporated), IPRATROPIUM BROMIDE (Bausch & Lomb Incorporated), IPRATROPIUM BROMIDE (Cardinal Health), IPRATROPIUM BROMIDE (Mylan Pharmaceuticals), IPRATROPIUM BROMIDE (Nephron SC), IPRATROPIUM BROMIDE (NuCare Pharmaceuticals), IPRATROPIUM BROMIDE (NuCare Pharmaceuticals), IPRATROPIUM BROMIDE (Preferred Pharmaceuticals), IPRATROPIUM BROMIDE (Proficient Rx LP), IPRATROPIUM BROMIDE (REMEDYREPACK), IPRATROPIUM BROMIDE (Ritedose Pharmaceuticals), IPRATROPIUM BROMIDE (West-Ward Pharmaceuticals Corp.), IPRATROPIUM BROMIDE (West-Ward Pharmaceuticals Corp.)
Formula
C20H30NO3. Br. H2O
Exact mass
429.1515
Mol weight
430.3764
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
Therapeutic category: 2259
ATC code: R01AX03 R03BB01
Product: D02212<JP/US>
Product (mixture): D10256<US>
Efficacy
Bronchodilator, Muscarinic acetylcholine receptor antagonist
  Disease
Chronic obstructive pulmonary disease [DS:H01714]
Emphysema [DS:H01714]
Comment
Tropane derivative, Quaternary ammonium compound
Target
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX03 Ipratropium bromide
      D02212  Ipratropium bromide (USAN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BB Anticholinergics
     R03BB01 Ipratropium bromide
      D02212  Ipratropium bromide (USAN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Anticholinergic
   Ipratropium
    D02212  Ipratropium bromide (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D02212  Ipratropium bromide (USAN); Ipratropium bromide hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D02212  Ipratropium bromide (USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02212  Ipratropium bromide hydrate
BRITE hierarchy
Other DBs
CAS: 22254-24-6
PubChem: 7849272
ChEBI: 5957
ChEMBL: CHEMBL2134724
DrugBank: DB00332
LigandBox: D02212
NIKKAJI: J252.827D
KCF data Show

ATOM        26
            1   O0  O    36.0414  -15.4183
            2   C1x C    21.9338  -15.2408
            3   C1x C    22.2619  -14.0691
            4   C1y C    23.1055  -14.9596
            5   C1y C    23.4336  -13.7879
            6   N2y N    22.1682  -12.4756 #+
            7   C1x C    24.9802  -14.9596
            8   C1x C    24.6990  -13.7879
            9   C1y C    26.0113  -15.5220
            10  O7a O    27.0893  -16.4125
            11  C7a C    28.3079  -16.4125
            12  C1c C    28.9172  -15.3345
            13  O6a O    28.9172  -17.5373
            14  C8y C    30.1358  -15.3345
            15  C1b C    28.3079  -14.3034
            16  O1a O    28.9172  -13.2255
            17  C8x C    30.8420  -16.5582
            18  C8x C    32.2420  -16.5585
            19  C8x C    32.9422  -15.3462
            20  C8x C    32.2361  -14.1225
            21  C8x C    30.8361  -14.1222
            22  C1a C    21.4191  -11.2914
            23  C1c C    20.9389  -13.0883
            24  C1a C    19.7662  -12.3118
            25  C1a C    20.9231  -14.4879
            26  X   Br   25.9700  -11.4800 #-
BOND        26
            1     2   3 1
            2     2   4 1
            3     3   5 1
            4     4   6 1
            5     4   7 1
            6     5   8 1
            7     7   9 1
            8     9  10 1 #Down
            9    10  11 1
            10   11  12 1
            11   11  13 2
            12   12  14 1
            13   12  15 1
            14   15  16 1
            15    5   6 1
            16    8   9 1
            17   14  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   14  21 1
            23    6  22 1
            24    6  23 1
            25   23  24 1
            26   23  25 1

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