KEGG   DRUG: Levallorphan tartrateHelp
Entry
D02238                      Drug                                   

Name
Levallorphan tartrate (JP17);
Lorfan (TN)
Formula
C19H25NO. C4H6O6
Exact mass
433.2101
Mol weight
433.4947
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 2213
Product: D02238<JP>
Product (mixture): D03855<JP>
Efficacy
Narcotic antagonist, Respiratory stimulant, Opioid receptor agonist/antagonist
Comment
Morphinan derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   221  Respiratory stimulants
    2213  Dimorpholamines
     D02238  Levallorphan tartrate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D02238  Levallorphan tartrate (JP17) <JP>
    OPRK1
     D02238  Levallorphan tartrate (JP17) <JP>
    OPRD1
     D02238  Levallorphan tartrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02238  Levallorphan tartrate
  D02238  Levallorphan tartrate injection
BRITE hierarchy
Other DBs
CAS: 71-82-9
PubChem: 7849297
DrugBank: DB00504
LigandBox: D02238
NIKKAJI: J252.875D
KCF data Show

ATOM        31
            1   O6a O    21.1500   -8.9104
            2   C6a C    22.3114   -8.2135
            3   C1c C    23.5193   -8.9104
            4   C1c C    24.7271   -8.2135
            5   C6a C    25.9350   -8.9104
            6   O6a O    27.1429   -8.2135
            7   O6a O    22.3114   -6.8198
            8   O1a O    23.5193  -10.3505
            9   O1a O    24.7271   -6.8198
            10  O6a O    25.9350  -10.3505
            11  C1z C    13.4694   -9.3694
            12  C8y C    13.4694   -8.0454
            13  C1y C    14.6540  -10.0661
            14  C1x C    12.3545   -9.9965
            15  C1x C    14.6540   -8.7423
            16  C8x C    12.3545   -7.4183
            17  C8y C    14.6540   -7.4183
            18  C1y C    15.7689   -9.3694
            19  C1x C    14.6540  -11.3204
            20  C1x C    12.3545  -11.3204
            21  C1x C    16.8837   -8.7423
            22  C8y C    12.3545   -6.0944
            23  C1x C    15.7689   -8.1151
            24  C8x C    14.6540   -6.0944
            25  N1y N    16.8837  -10.0661
            26  C1x C    13.4694  -12.0172
            27  C8x C    13.5391   -5.4673
            28  O1a O    11.2397   -5.4673
            29  C1b C    18.2826  -10.0661
            30  C2b C    18.9855  -11.2834
            31  C2a C    20.3699  -11.2832
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     3   8 1 #Up
            8     4   9 1 #Up
            9     5  10 2
            10   11  12 1
            11   11  13 1
            12   11  14 1
            13   11  15 1 #Up
            14   12  16 2
            15   12  17 1
            16   13  18 1
            17   13  19 1
            18   14  20 1
            19   15  21 1
            20   16  22 1
            21   17  23 1
            22   17  24 2
            23   18  25 1 #Up
            24   19  26 1
            25   22  27 2
            26   22  28 1
            27   18  23 1
            28   20  26 1
            29   21  25 1
            30   24  27 1
            31   25  29 1
            32   29  30 1
            33   30  31 2

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