KEGG   DRUG: Erythromycin gluceptateHelp
Entry
D02524                      Drug                                   

Name
Erythromycin gluceptate (USP);
Erythromycin glucoheptonate;
Ilotycin gluceptate (TN)
Formula
C37H67NO13. C7H14O8
Exact mass
959.5301
Mol weight
960.108
Structure
Mol fileKCF fileDB search
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A inhibitor
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02524  Erythromycin gluceptate (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02524  Erythromycin gluceptate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02524  Erythromycin gluceptate (USP)
BRITE hierarchy
Other DBs
CAS: 23067-13-2
PubChem: 17396698
ChEMBL: CHEMBL3545060
DrugBank: DB00199
LigandBox: D02524
NIKKAJI: J244.808D
KCF data Show

ATOM        66
            1   C1c C    33.7070  -21.6382
            2   C1c C    34.9626  -22.3357
            3   C1c C    32.5213  -22.3357
            4   O1a O    33.7070  -20.2431
            5   C1c C    36.1483  -21.6382
            6   O1a O    34.8928  -23.7308
            7   C1c C    31.2657  -21.6382
            8   O1a O    32.5213  -23.7308
            9   C6a C    37.3342  -22.3357
            10  O1a O    36.1483  -20.2431
            11  C1b C    30.0799  -22.3357
            12  O1a O    31.2657  -20.2431
            13  O6a O    37.3342  -23.7308
            14  O6a O    38.5199  -21.6382
            15  O1a O    28.8940  -21.7080
            16  C1y C    21.3277  -17.1158
            17  C1z C    21.3277  -15.7501
            18  C1y C    20.1414  -17.7929
            19  O2a O    23.3125  -17.8334
            20  C1x C    20.1414  -15.0672
            21  O1a O    22.3577  -14.7606
            22  C1a C    22.6123  -16.1840
            23  C1y C    20.1414  -19.1586
            24  C1a C    19.1690  -16.7693
            25  C1y C    24.8932  -17.1173
            26  C1y C    20.1414  -13.6957
            27  O2a O    20.8822  -20.5184
            28  C1y C    18.9668  -19.8416
            29  C1y C    26.0634  -17.8097
            30  O2x O    24.9052  -15.7521
            31  C5x C    18.9668  -13.0186
            32  C1a C    21.3277  -13.0186
            33  C1y C    22.4009  -20.9371
            34  C7x C    17.7805  -19.1586
            35  C1a C    18.9668  -21.2070
            36  C1y C    27.2511  -17.1469
            37  O1a O    26.0543  -19.1800
            38  C1y C    26.0978  -15.0866
            39  C1y C    17.7805  -13.6957
            40  O5x O    18.9668  -11.6529
            41  C1x C    22.4009  -22.2971
            42  O2x O    23.5873  -20.2543
            43  O7x O    17.7805  -17.7929
            44  O6a O    16.7214  -20.1077
            45  C1x C    27.2655  -15.7868
            46  N1c N    28.4262  -17.8366
            47  C1a C    26.1175  -13.7236
            48  C1y C    17.7805  -15.0672
            49  C1a C    16.6000  -13.0186
            50  C1z C    23.5873  -22.9857
            51  C1y C    24.7619  -20.9371
            52  C1y C    16.6000  -17.1158
            53  C1z C    16.6000  -15.7501
            54  O1a O    18.9668  -15.7501
            55  C1y C    24.7619  -22.2971
            56  O2a O    23.5873  -24.3109
            57  C1a C    25.0340  -23.9695
            58  C1a C    25.9482  -20.2601
            59  C1b C    15.4194  -17.7929
            60  C1a C    15.3500  -16.3170
            61  O1a O    15.3500  -15.0615
            62  O1a O    25.9482  -22.9857
            63  C1a C    24.6867  -25.2716
            64  C1a C    15.4544  -18.9155
            65  C1a C    29.6747  -17.1278
            66  C1a C    28.4167  -19.2008
BOND        67
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     3   8 1 #Down
            8     5   9 1
            9     5  10 1 #Up
            10    7  11 1
            11    7  12 1 #Up
            12    9  13 2
            13    9  14 1
            14   11  15 1
            15   16  17 1
            16   16  18 1
            17   16  19 1 #Down
            18   17  20 1
            19   17  21 1 #Up
            20   17  22 1 #Down
            21   18  23 1
            22   18  24 1 #Down
            23   25  19 1 #Down
            24   20  26 1
            25   23  27 1 #Down
            26   23  28 1
            27   25  29 1
            28   25  30 1
            29   26  31 1
            30   26  32 1 #Down
            31   33  27 1 #Down
            32   28  34 1
            33   28  35 1 #Up
            34   29  36 1
            35   29  37 1 #Up
            36   30  38 1
            37   31  39 1
            38   31  40 2
            39   33  41 1
            40   33  42 1
            41   34  43 1
            42   34  44 2
            43   36  45 1
            44   36  46 1 #Down
            45   38  47 1 #Down
            46   39  48 1
            47   39  49 1 #Up
            48   41  50 1
            49   42  51 1
            50   43  52 1
            51   48  53 1
            52   48  54 1 #Up
            53   50  55 1
            54   50  56 1 #Down
            55   50  57 1
            56   51  58 1 #Up
            57   52  59 1 #Down
            58   53  60 1 #Down
            59   53  61 1 #Up
            60   55  62 1 #Down
            61   56  63 1
            62   59  64 1
            63   38  45 1
            64   51  55 1
            65   52  53 1
            66   46  65 1
            67   46  66 1

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