KEGG   DRUG: Valganciclovir hydrochloride
Entry
D03256                      Drug                                   

Name
Valganciclovir hydrochloride (JAN/USP);
Valcyte (TN)
Product
  Generic
Formula
C14H22N6O5. HCl
Exact mass
390.1418
Mol weight
390.8226
Structure
Simcomp
Class
Antiviral
 DG02840  Herpesvirus DNA polymerase inhibitor
 DG01937  Anti-cytomegalovirus agent
Remark
Therapeutic category: 6250
ATC code: J05AB14
Chemical structure group: DG00649
Product (DG00649): D03256<JP/US>
Efficacy
Antiviral, DNA polymerase inhibitor
  Disease
Cytomegalovirus (CMV) retinitis [DS:H00368]
Comment
Active form of prodrug: Ganciclovir [DR:D00333]
Target
Herpesvirus DNA polymerase [KO:K18964]
Interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB14 Valganciclovir
      D03256  Valganciclovir hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Valganciclovir
    D03256  Valganciclovir hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D03256  Valganciclovir hydrochloride (JAN/USP)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03256
Prodrugs [br08324.html]
 DG00649
Other DBs
CAS: 175865-59-5
PubChem: 17397409
ChEMBL: CHEMBL1200454
LigandBox: D03256
KCF data

ATOM        26
            1   C8y C    27.4400  -16.6600
            2   C8y C    27.4400  -15.2600
            3   N4y N    26.1800  -17.2200
            4   N4x N    28.7700  -17.3600
            5   N5x N    26.1100  -14.9100
            6   C8y C    28.5600  -14.4900
            7   C8x C    25.3400  -16.1000
            8   C8y C    29.8900  -16.5900
            9   N5x N    29.8900  -15.1200
            10  O5x O    28.5600  -13.0900
            11  N1a N    31.1500  -17.2200
            12  C1b C    26.1800  -18.6200
            13  O2a O    24.9900  -19.3200
            14  C1c C    23.8000  -18.6200
            15  C1b C    22.6100  -19.3200
            16  C1b C    23.8000  -17.2200
            17  O7a O    21.4200  -18.6900
            18  C7a C    20.2300  -19.3200
            19  C1c C    19.0400  -18.6900
            20  C1c C    17.8500  -19.3200
            21  O1a O    22.6100  -16.5900
            22  O6a O    20.2300  -20.7900
            23  C1a C    16.6600  -18.6900
            24  C1a C    17.8500  -20.7900
            25  N1a N    19.0400  -17.2200
            26  X   Cl   34.6500  -15.8900
BOND        26
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     6   9 1
            9     6  10 2
            10    8  11 1
            11    5   7 2
            12    8   9 2
            13    3  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   16  21 1
            23   18  22 2
            24   20  23 1
            25   20  24 1
            26   19  25 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system