KEGG   DRUG: Choriogonadotropin alfa
Entry
D03478                      Drug                                   
Name
Choriogonadotropin alfa (USAN/INN);
Choriogonadotropin alfa (genetical recombination) (JAN);
Ovidrel (TN)
Product
CHORIONIC GONADOTROPIN (Fresenius Kabi USA), OVIDREL (EMD Serono)
Sequence
(alpha-subunit) APDVQDCPEC TLQENPFFSQ PGAPILQCMG CCFSRAYPTP
LRSKKTMLVQ KNVTSESTCC VAKSYNRVTV MGGFKVENHT ACHCSTCYYH KS
(Glycosylation site: 52; 78)
(beta-subunit) SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT
MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ
(Glycosylation site: 13; 30; 121; 127; 132; 138)
  Type
Peptide
Remark
Therapeutic category: 2413
ATC code: G03GA08
Product: D03478<JP/US>
Efficacy
Ovulation inducing agent, Luteinizing hormone/choriogonadotropin receptor agonist
  Disease
Hypogonadotropic hypogonadism [DS:H00255]
Comment
Gonadotropin, chorionic (human alfa-subunit protein moiety reduced), complex with chorionic gonadotropin (human beta-subunit protein moiety reduced)
alfa-Subunit [DR:D04429]
beta-Subunit (CAS 56832-34-9)
Treatment of infertility, Cryptorchidism therapy adjuvant (recombinant human chorionic gonadotropin (rhCG))
Target
LHCGR [HSA:3973] [KO:K04248]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
  Network
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03G GONADOTROPINS AND OTHER OVULATION STIMULANTS
    G03GA Gonadotropins
     G03GA08 Choriogonadotropin alfa
      D03478  Choriogonadotropin alfa (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
  Choriogonadotropin Alfa
   D03478  Choriogonadotropin alfa (USAN/INN)
 Infertility Agents
  Choriogonadotropin Alfa
   D03478  Choriogonadotropin alfa (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   241  Pituitary hormone preparations
    2413  Gonadotropic hormones
     D03478  Choriogonadotropin alfa (USAN/INN); Choriogonadotropin alfa (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Lutropin-choriogonadotropic hormone
    LHCGR
     D03478  Choriogonadotropin alfa (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03478
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03478
Other DBs
CAS: 177073-44-8
PubChem: 17397614

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Ontology (6)   
   KEGG BRITE (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (10)   

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