KEGG   DRUG: DenosumabHelp
Entry
D03684                      Drug                                   

Name
Denosumab (USAN);
Denosumab (genetical recombination) (JAN);
Prolia (TN);
Ranmark (TN);
Xgeva (TN)
Product
Formula
C6404H9912N1724O2004S50
Exact mass
144631.2737
Mol weight
144720.8225
Remark
Therapeutic category: 3999
ATC code: M05BX04
Product: D03684<JP/US>
Efficacy
Osteoporosis agent, Anti-RANKL antibody
  Disease
Osteoporosis [DS:H01593]
Giant cell tumor of bone [DS:H01470]
Comment
Monoclonal antibody
Target
TNFSF11 (RANKL, CD254) [HSA:8600] [KO:K05473]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04380  Osteoclast differentiation
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BX Other drugs affecting bone structure and mineralization
     M05BX04 Denosumab
      D03684  Denosumab (USAN) <JP/US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Denosumab
   D03684  Denosumab (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03684  Denosumab (USAN); Denosumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF11 (RANKL, CD254)
     D03684  Denosumab (USAN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Osteoporosis drugs
  D03684
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03684
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03684
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03684
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03684
BRITE hierarchy
Other DBs
CAS: 615258-40-7
PubChem: 17397780

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