KEGG   DRUG: Rivastigmine
Entry
D03822                      Drug                                   

Name
Rivastigmine (JAN/USP/INN);
Exelon (TN);
Prometax (TN)
Product
  Generic
Formula
C14H22N2O2
Exact mass
250.1681
Mol weight
250.3367
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
  DG01594  Butyrylcholinesterase inhibitor
 DG01968  Agents for Alzheimer-type dementia
Remark
Same as: C11766
Therapeutic category: 1190
ATC code: N06DA03
Chemical structure group: DG00984
Product (DG00984): D03822<JP/US> D02558<US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
  Disease
Alzheimer's disease [DS:H00056]
Comment
Physostigmine derivative
Target
ACHE [HSA:43] [KO:K01049]
BCHE [HSA:590] [KO:K01050]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D03822  Rivastigmine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D03822  Rivastigmine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D03822  Rivastigmine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D03822  Rivastigmine (JAN/USP/INN) <JP/US>
    BCHE
     D03822  Rivastigmine (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03822
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03822
Other DBs
CAS: 123441-03-2
PubChem: 17397908
ChEBI: 8874
ChEMBL: CHEMBL636
DrugBank: DB00989
LigandBox: D03822
NIKKAJI: J982.502I
KCF data

ATOM        18
            1   C8y C    33.4600  -18.9700
            2   C8x C    34.6500  -18.2700
            3   C8x C    33.4600  -20.3700
            4   O7a O    32.2000  -18.2700
            5   C8y C    35.8400  -18.9700
            6   C8x C    34.6500  -21.0700
            7   C7a C    31.0100  -18.9700
            8   C8x C    35.8400  -20.3700
            9   N1c N    29.8200  -18.2700
            10  O6a O    31.0100  -20.3700
            11  C1a C    28.5600  -18.9700
            12  C1c C    37.1000  -18.2700
            13  N1c N    38.2900  -18.9700
            14  C1a C    37.1000  -16.8700
            15  C1a C    38.2900  -20.3700
            16  C1a C    39.4800  -18.2700
            17  C1b C    29.8200  -16.8700
            18  C1a C    31.0800  -16.1700
BOND        18
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    9  17 1
            17    4   7 1
            18   17  18 1

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