Entry |
|
Name |
Flordipine (USAN/INN) |
Formula |
C26H33F3N2O5
|
Exact mass |
510.2342
|
Mol weight |
510.54
|
Structure |
|
Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
|
Efficacy |
Antihypertensive, Calcium channel blocker |
Comment |
Dihydropyridine derivative
|
Target |
|
Pathway |
hsa04261 | Adrenergic signaling in cardiomyocytes |
hsa04270 | Vascular smooth muscle contraction |
|
Interaction |
|
Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
D04193 Flordipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D04193 Flordipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D04193 Flordipine (USAN/INN)
|
Other DBs |
|
KCF data |
ATOM 36
1 C1y C 31.3181 -17.0259
2 C8y C 31.3064 -20.3346
3 C2y C 32.4647 -16.3766
4 C2y C 30.1713 -16.3766
5 C8y C 30.1538 -20.9958
6 C8x C 32.4472 -20.9958
7 C2y C 32.4647 -15.0542
8 C7a C 33.6114 -17.0259
9 C2y C 30.1713 -15.0542
10 C7a C 29.0362 -17.0259
11 C8x C 30.1538 -22.3063
12 C1d C 29.0305 -20.3346
13 C8x C 32.4472 -22.3063
14 N1y N 31.3181 -14.3932
15 C1a C 33.6114 -14.3932
16 O7a O 34.7465 -16.3766
17 O6a O 33.6114 -18.3540
18 C1a C 29.0362 -14.3932
19 O7a O 27.8954 -16.3766
20 O6a O 29.0422 -18.2544
21 C8x C 31.3064 -22.9790
22 C1b C 35.8814 -17.0259
23 C1b C 26.7546 -17.0259
24 C1a C 37.0164 -16.3706
25 C1a C 25.5287 -16.3081
26 X F 27.8180 -19.6346
27 X F 29.7556 -19.0908
28 X F 28.3454 -21.5098
29 C1b C 31.3176 -13.0203
30 C1b C 32.5091 -12.3317
31 N1y N 32.5087 -10.9203
32 C1x C 33.6994 -10.2322
33 C1x C 33.6988 -8.8322
34 O2x O 32.4861 -8.1327
35 C1x C 31.2954 -8.8208
36 C1x C 31.2960 -10.2208
BOND 38
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 2
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 1
18 10 19 1
19 10 20 2
20 11 21 1
21 16 22 1
22 19 23 1
23 22 24 1
24 9 14 1
25 13 21 2
26 23 25 1
27 12 26 1
28 12 27 1
29 12 28 1
30 14 29 1
31 29 30 1
32 30 31 1
33 31 32 1
34 32 33 1
35 33 34 1
36 34 35 1
37 35 36 1
38 31 36 1
|