KEGG   DRUG: Guanethidine monosulfate
Entry
D04382                      Drug                                   

Name
Guanethidine monosulfate (USP);
Guanethidine sulfate (JP17);
Ismelin (TN)
Formula
C10H22N4. H2SO4
Exact mass
296.1518
Mol weight
296.387
Structure
Class
Cardiovascular agent
 DG01739  Peripherally-acting antiadrenergic
Remark
ATC code: C02CC02 S01EX01
Chemical structure group: DG00258
Efficacy
Antihypertensive, Noradrenaline release inhibitor
Comment
Guanidine derivative
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CC Guanidine derivatives
     C02CC02 Guanethidine
      D04382  Guanethidine monosulfate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX01 Guanethidine
      D04382  Guanethidine monosulfate (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D04382  Guanethidine monosulfate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D04382  Guanethidine sulfate
Other DBs
CAS: 645-43-2
PubChem: 47206277
ChEBI: 51016
ChEMBL: CHEMBL1345
DrugBank: DB01170
LigandBox: D04382
NIKKAJI: J237.257F
KCF data

ATOM        19
            1   N1y N    21.4998  -15.4594
            2   C1b C    20.2881  -14.7604
            3   C1x C    21.4998  -16.9041
            4   C1x C    22.5250  -14.4341
            5   C1b C    19.1231  -15.4594
            6   C1x C    22.4784  -17.8828
            7   C1x C    23.9230  -14.4341
            8   N1b N    17.9581  -14.7604
            9   C1x C    23.9230  -17.8828
            10  C1x C    24.9017  -15.4128
            11  C2c C    16.7464  -15.4594
            12  C1x C    24.9017  -16.9041
            13  N1a N    15.5813  -14.7604
            14  N2a N    16.7464  -16.8109
            15  S4a S    30.1701  -16.4848
            16  O1d O    30.1701  -15.0862
            17  O1d O    30.1701  -17.8833
            18  O1d O    31.5686  -16.4848
            19  O1d O    28.7716  -16.4848
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 2
            14   10  12 1
            15   15  16 2
            16   15  17 2
            17   15  18 1
            18   15  19 1

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