| Entry |
|
|---|
| Name |
Lacidipine (USAN/INN);
Motens (TN) |
|---|
| Formula |
C26H33NO6
|
|---|
| Exact mass |
455.2308
|
|---|
| Mol weight |
455.5433
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA09 Lacidipine
D04657 Lacidipine (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D04657 Lacidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D04657 Lacidipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D04657 Lacidipine (USAN/INN)
|
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| Other DBs |
|
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| KCF data |
ATOM 33
1 C1y C 30.7658 -15.9980
2 C8y C 30.8182 -18.2612
3 C2y C 29.5904 -15.3231
4 C2y C 31.9409 -15.3290
5 C8x C 29.6371 -18.9361
6 C8y C 31.9935 -18.9478
7 C2y C 29.5963 -13.9617
8 C7a C 28.4093 -15.9923
9 C2y C 31.9468 -13.9734
10 C7a C 33.1104 -16.0096
11 C8x C 29.6371 -20.2975
12 C8x C 31.9877 -20.2975
13 N1x N 30.7715 -13.2868
14 C1a C 28.4209 -13.2811
15 O7a O 27.2400 -15.3174
16 O6a O 28.4093 -17.3594
17 C1a C 33.1220 -13.2928
18 O7a O 34.2914 -15.3406
19 O6a O 33.1046 -17.3710
20 C8x C 30.8066 -20.9782
21 C1b C 26.0648 -15.9923
22 C1b C 35.4667 -16.0212
23 C1a C 24.8895 -15.3115
24 C1a C 36.6913 -15.3163
25 C2b C 33.2154 -18.2501
26 C2b C 34.3974 -18.9401
27 C7a C 35.5884 -18.2599
28 O7a O 36.7621 -18.9450
29 O6a O 35.5258 -16.8532
30 C1d C 37.9573 -18.2623
31 C1a C 39.3583 -17.4419
32 C1a C 38.6325 -19.4451
33 C1a C 37.2518 -17.0264
BOND 34
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 7 14 1
14 8 15 1
15 8 16 2
16 9 17 1
17 10 18 1
18 10 19 2
19 11 20 2
20 15 21 1
21 18 22 1
22 21 23 1
23 9 13 1
24 12 20 1
25 22 24 1
26 6 25 1
27 25 26 2
28 26 27 1
29 27 28 1
30 27 29 2
31 28 30 1
32 30 31 1
33 30 32 1
34 30 33 1
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