KEGG   DRUG: Lofexidine hydrochlorideHelp
Entry
D04765                      Drug                                   

Name
Lofexidine hydrochloride (USAN);
Lofexidine (TN);
Lucemyra (TN)
Product
Formula
C11H12Cl2N2O. HCl
Exact mass
294.0093
Mol weight
295.5927
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
ATC code: N07BC04
Chemical structure group: DG01001
Product (DG01001): D04765<US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
Comment
Mitigation of opioid withdrawal symptoms to facilitate abrupt opioid discontinuation
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC04 Lofexidine
      D04765  Lofexidine hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Dependence
   Lofexidine
    D04765  Lofexidine hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D04765  Lofexidine hydrochloride (USAN) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D04765
BRITE hierarchy
Other DBs
CAS: 21498-08-8
PubChem: 47206580
ChEMBL: CHEMBL1788132
LigandBox: D04765
NIKKAJI: J586.627H
KCF data Show

ATOM        17
            1   C8x C    27.1048  -17.3043
            2   C8x C    27.1048  -18.7100
            3   C8x C    28.3222  -19.4128
            4   C8y C    29.5396  -18.7100
            5   C8y C    29.5396  -17.3043
            6   C8y C    28.3222  -16.6014
            7   X   Cl   28.3222  -15.1959
            8   X   Cl   30.7757  -19.4239
            9   O2a O    30.7757  -16.5904
            10  C1c C    31.9858  -17.2889
            11  C2y C    33.1729  -16.6033
            12  C1a C    31.9862  -18.7096
            13  N1x N    34.4884  -17.0360
            14  C1x C    35.3055  -15.9197
            15  C1x C    34.4963  -14.7978
            16  N2x N    33.1792  -15.2206
            17  X   Cl   37.0150  -17.9368
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     4   8 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   10  12 1
            13   11  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   11  16 2

» Japanese version   » Back

DBGET integrated database retrieval system