KEGG   DRUG: Memantine hydrochlorideHelp
Entry
D04905                      Drug                                   

Name
Memantine hydrochloride (JAN/USAN);
Namenda (TN);
Memary (TN)
Product
  Generic
MEMANTINE (American Health Packaging), MEMANTINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), MEMANTINE HYDROCHLORIDE (AvKARE), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE (Cardinal Health), MEMANTINE (Dr. Reddys Laboratories Limited), MEMANTINE (Major Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Mylan Institutional), MEMANTINE HYDROCHLORIDE (Mylan Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Mylan Pharmaceuticals), MEMANTINE (NCS HealthCare of KY), MEMANTINE HYDROCHLORIDE (Ajanta Pharma Limited), MEMANTINE HYDROCHLORIDE (Alembic Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), MEMANTINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MEMANTINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MEMANTINE (Apotex Corp.), MEMANTINE HYDROCHLORIDE (Aurobindo Pharma Limited), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Cadila Healthcare Limited), MEMANTINE HYDROCHLORIDE (Cadila Healthcare Limited), MEMANTINE HYDROCHLORIDE (Contract Pharmacy Services-PA), MEMANTINE HYDROCHLORIDE (Golden State Medical Supply), MEMANTINE HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Lannett Company), MEMANTINE HYDROCHLORIDE (Lannett Company), MEMANTINE HYDROCHLORIDE (Lupin Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Lupin Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Par Pharmaceutical), MEMANTINE HYDROCHLORIDE (Patrin Pharma), MEMANTINE HYDROCHLORIDE (Preferred Pharmaceuticals), MEMANTINE HYDROCHLORIDE (PuraCap Pharmaceutical LLC), MEMANTINE HYDROCHLORIDE (Silarx Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Strides Shasun Limited), MEMANTINE HYDROCHLORIDE (Sun Pharma Global FZE), MEMANTINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), MEMANTINE HYDROCHLORIDE (Upsher-Smith Laboratories), MEMANTINE HYDROCHLORIDE (Vivimed Labs Limited), MEMANTINE HYDROCHLORIDE (Wockhardt USA LLC.), MEMANTINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), MEMANTINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), MEMATINE HYDROCHLORIDE (Orchid Chemicals & Pharmaceuticals Limited)
Formula
C12H21N. HCl
Exact mass
215.1441
Mol weight
215.7628
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
 DG01968  Agents for Alzheimer-type dementia
Unclassified
 DG02854  SLC22A2 substrate
Remark
Therapeutic category: 1190
ATC code: N06DX01
Chemical structure group: DG00986
Product (DG00986): D04905<JP/US>
Efficacy
Dementia therapeutic agent, NMDA receptor antagonist
  Disease
Alzheimer's disease [DS:H00056]
Comment
Adamantane derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer's disease
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07235  N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX01 Memantine
      D04905  Memantine hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antidementia Agents
  N-methyl-D-aspartate (NMDA) Receptor Antagonist
   Memantine
    D04905  Memantine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D04905  Memantine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D04905  Memantine hydrochloride (JAN/USAN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D04905
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D04905
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04905
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04905
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04905
BRITE hierarchy
Other DBs
CAS: 41100-52-1
PubChem: 47206665
ChEBI: 64323
ChEMBL: CHEMBL1699 CHEMBL3213320
DrugBank: DB01043
LigandBox: D04905
NIKKAJI: J299.313I
KCF data Show

ATOM        14
            1   C1x C    24.5248  -18.7456
            2   C1z C    24.5248  -20.1058
            3   C1x C    25.7055  -20.7858
            4   C1z C    26.8792  -20.1058
            5   C1x C    26.8792  -18.7456
            6   C1z C    25.7055  -18.0656
            7   C1x C    23.5563  -21.0675
            8   C1y C    24.9163  -21.0675
            9   C1x C    26.2284  -21.4178
            10  C1a C    28.1860  -20.4561
            11  C1a C    23.2060  -20.4561
            12  N1a N    25.7073  -16.7056
            13  C1x C    24.9096  -19.4326
            14  X   Cl   32.0600  -19.7400
BOND        15
            1     2   7 1
            2     1   2 1
            3     7   8 1
            4     2   3 1
            5     8   9 1
            6     9   4 1
            7     3   4 1
            8     4  10 1
            9     4   5 1
            10    2  11 1
            11    5   6 1
            12    6  12 1
            13    6   1 1
            14    8  13 1
            15    6  13 1

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