KEGG   DRUG: Napamezole hydrochlorideHelp
Entry
D05119                      Drug                                   

Name
Napamezole hydrochloride (USAN)
Formula
C14H16N2. HCl
Exact mass
248.108
Mol weight
248.7512
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Efficacy
Antidepressant
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D05119  Napamezole hydrochloride (USAN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D05119  Napamezole hydrochloride (USAN)
    SLC6A3 (DAT1)
     D05119  Napamezole hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 87495-33-8
PubChem: 47206844
ChEMBL: CHEMBL553031
LigandBox: D05119
KCF data Show

ATOM        17
            1   C8x C    26.1212  -16.4731
            2   C8x C    26.1212  -17.8749
            3   C8x C    27.3351  -18.5758
            4   C8y C    28.5492  -17.8749
            5   C8y C    28.5492  -16.4731
            6   C8x C    27.3351  -15.7722
            7   C1x C    29.7631  -18.5758
            8   C1x C    30.9771  -17.8749
            9   C2y C    30.9771  -16.4731
            10  C2x C    29.7631  -15.7722
            11  C1b C    32.1762  -15.7807
            12  C2y C    33.3660  -16.4676
            13  N2x N    33.3676  -17.8694
            14  C1x C    34.7042  -18.3003
            15  C1x C    35.5271  -17.1623
            16  N1x N    34.6989  -16.0280
            17  X   Cl   38.0364  -17.9450
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   12  16 1

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