KEGG   DRUG: Norepinephrine bitartrateHelp
Entry
D05206                      Drug                                   

Name
Norepinephrine bitartrate (USP);
Levophed (TN)
Product
  Generic
  Other
Formula
C8H11NO3. C4H6O6. H2O
Exact mass
337.1009
Mol weight
337.28
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Remark
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
  Disease
Myocardial infarction [DS:H01730]
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D05206  Norepinephrine bitartrate (USP) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D05206  Norepinephrine bitartrate (USP) <US>
    ADRA2
     D05206  Norepinephrine bitartrate (USP) <US>
    ADRB
     D05206  Norepinephrine bitartrate (USP) <US>
BRITE hierarchy
Other DBs
CAS: 69815-49-2
PubChem: 47206925
DrugBank: DB00368
LigandBox: D05206
KCF data Show

ATOM        23
            1   C8y C    35.0700  -25.6900
            2   C8x C    35.0700  -27.0900
            3   C8x C    33.8100  -24.9900
            4   C1c C    36.2600  -24.9900
            5   C8x C    33.8100  -27.7900
            6   C8y C    32.6200  -25.6900
            7   C1b C    37.4500  -25.6900
            8   O1a O    36.2600  -23.5900
            9   C8y C    32.6200  -27.0900
            10  N1a N    38.6400  -24.9900
            11  O1a O    31.4300  -27.7900
            12  O1a O    31.4300  -24.9900
            13  O6a O    41.7200  -26.1100
            14  C6a C    42.9800  -25.4100
            15  C1c C    44.1700  -26.1100
            16  C1c C    45.3600  -25.4100
            17  C6a C    46.6200  -26.1100
            18  O6a O    47.8100  -25.4100
            19  O6a O    42.9800  -24.0100
            20  O1a O    44.1700  -27.5100
            21  O1a O    45.3600  -24.0100
            22  O6a O    46.6200  -27.5100
            23  O0  O    51.8700  -26.3200
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   14  19 2
            19   15  20 1 #Up
            20   16  21 1 #Up
            21   17  22 2

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