KEGG   DRUG: OnerceptHelp
Entry
D05263                      Drug                                   

Name
Onercept (USAN/INN)
Formula
C753H1156N228O247S25
Exact mass
18143.7923
Mol weight
18156.2401
Sequence
DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL
SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFCCSLCL NGTVHLSCQE
KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE N
(Disulfide bridge: 4-18; 19-32; 22-41; 44-59; 62-77; 65-85; 87-103; 106-118; 109-126; 128-139; 142-151; 145-155)
  Type
Peptide
Class
Other
 DG01936  TNF inhibitor
Efficacy
Anti-inflammatory, TNF-alpha inhibitor
Comment
fusion protein
a recombinant human soluble type I TNF receptor (p55) [HSA:7132] [KO:K03158]
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04350  TGF-beta signaling pathway
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D05263  Onercept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 199685-57-9
PubChem: 47206972

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