KEGG   DRUG: SemaxanibHelp
Entry
D05819                      Drug                                   

Name
Semaxanib (USAN/INN)
Formula
C15H14N2O
Exact mass
238.1106
Mol weight
238.2845
Structure
Mol fileKCF fileDB search
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
Target
FLT3 (CD135) [HSA:2322] [KO:K05092]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa05200  Pathways in cancer
Interaction
Drug interaction
Structure map
map07045  Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    KIT (CD117)
     D05819  Semaxanib (USAN/INN)
    FLT3 (CD135)
     D05819  Semaxanib (USAN/INN)
   VEGFR family
    VEGFR2 (KDR)
     D05819  Semaxanib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 194413-58-6
PubChem: 47207480
ChEBI: 91083
ChEMBL: CHEMBL276711
PDB-CCD: X2M[PDBj]
LigandBox: D05819
KCF data Show

ATOM        18
            1   C8x C    17.9900  -18.9700
            2   C8x C    17.9900  -20.3700
            3   C8x C    19.1800  -21.0700
            4   C8y C    20.4400  -20.3700
            5   C8y C    20.4400  -18.9700
            6   C8x C    19.1800  -18.2700
            7   C2y C    21.7700  -20.7900
            8   C5x C    22.5400  -19.6700
            9   N1x N    21.7700  -18.5500
            10  O5x O    23.9400  -19.6700
            11  C2b C    21.7700  -22.1900
            12  C8y C    22.9600  -22.8900
            13  C8y C    22.9600  -24.2900
            14  C1a C    21.7000  -24.9900
            15  N4x N    24.2900  -22.4700
            16  C8y C    25.1300  -23.5900
            17  C8x C    24.2900  -24.7100
            18  C1a C    26.5300  -23.5900
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 2
            12    7  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   13  17 1
            20   16  18 1

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