KEGG   DRUG: TolamololHelp
Entry
D06176                      Drug                                   

Name
Tolamolol (USAN/INN)
Formula
C19H24N2O4
Exact mass
344.1736
Mol weight
344.4049
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
Efficacy
Antiarrhythmic, Cardiac depressant, Vasodilator, beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D06176  Tolamolol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 38103-61-6
PubChem: 47207834
ChEMBL: CHEMBL418192
LigandBox: D06176
NIKKAJI: J19.673H
KCF data Show

ATOM        25
            1   C8y C    27.5100  -18.9700
            2   C8x C    27.5100  -17.5700
            3   C8x C    26.2500  -16.8700
            4   C8y C    25.0600  -17.5700
            5   C8x C    25.0600  -18.9700
            6   C8x C    26.2500  -19.6700
            7   C5a C    28.7000  -19.6700
            8   N1a N    29.8900  -18.9700
            9   O5a O    28.7000  -21.0700
            10  O2a O    23.8000  -16.8700
            11  C1b C    22.6100  -17.5700
            12  C1b C    21.4200  -16.8700
            13  N1b N    20.2300  -17.5700
            14  C1b C    19.0400  -16.8700
            15  C1c C    17.8500  -17.5700
            16  C1b C    16.6600  -16.8700
            17  O1a O    17.8500  -18.9700
            18  O2a O    15.4700  -17.5700
            19  C8y C    15.4700  -18.9700
            20  C8y C    14.2576  -19.6700
            21  C8x C    14.2576  -21.0700
            22  C8x C    15.4700  -21.7700
            23  C8x C    16.6824  -21.0700
            24  C8x C    16.6824  -19.6700
            25  C1a C    13.0621  -18.9796
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 2
            10    4  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   15  17 1
            18   16  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   19  24 1
            26   20  25 1

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